S
Sachintha M. Jayasinghe
Researcher at Stowers Institute for Medical Research
Publications - 5
Citations - 1343
Sachintha M. Jayasinghe is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Neural crest & Treacle. The author has an hindex of 5, co-authored 5 publications receiving 1274 citations.
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Journal ArticleDOI
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Jiwang Zhang,Justin C. Grindley,Tong Yin,Sachintha M. Jayasinghe,Xi C. He,Jason Ross,Jeffrey S. Haug,Dawn E Rupp,Kimberly S. Porter-Westpfahl,Leanne M. Wiedemann,Leanne M. Wiedemann,Hong Wu,Linheng Li,Linheng Li +13 more
TL;DR: It is shown that inactivation of PTEN in bone marrow HSCs causes their short-term expansion, but long-term decline, primarily owing to an enhanced level of HSC activation.
Journal ArticleDOI
Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities
Jill Dixon,Natalie Carmaline Jones,Lisa L. Sandell,Sachintha M. Jayasinghe,Jennifer F Crane,Jean-Phillipe Rey,Michael J. Dixon,Paul A. Trainor +7 more
TL;DR: Tcof1/Treacle is a unique spatiotemporal regulator of ribosome biogenesis, a deficiency that disrupts neural crest cell formation and proliferation, causing the hypoplasia characteristic of TCS craniofacial anomalies.
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Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Jacqueline Kim Dale,Pascale Malapert,Jérome Chal,Gonçalo C. Vilhais-Neto,Miguel Maroto,Teri Johnson,Sachintha M. Jayasinghe,Paul A. Trainor,Bernhard G. Herrmann,Olivier Pourquié +9 more
TL;DR: Snail genes define a class of cyclic genes that coordinate segmentation and PSM morphogenesis, and it is shown that they require WNT and FGF signaling.
Journal ArticleDOI
Sterile and disposable fluidic subsystem suitable for clinical high speed fluorescence- activated cell sorting
Sachintha M. Jayasinghe,Joshua P. Wunderlich,Angel McKee,Heather Newkirk,Steve Pope,Jiwang Zhang,Karen Staehling-Hampton,Linheng Li,Jeffrey S. Haug +8 more
TL;DR: Applications of fluorescence‐activated cell sorting (FACS) are ideally performed under aseptic conditions so that isolated cells can be successfully cultured, transplanted, or processed for the isolation of protein and nucleic acids.
Tcof1/Treacle is required for neural crest stem cell formation and proliferation through its role in mature ribosome production, deficiencies in which cause craniofacial abnormalities
Joanne Dixon,Natalie Carmaline Jones,Lisa L. Sandell,Sachintha M. Jayasinghe,Jennifer F Crane,Jean-Phillipe Rey,Michael J. Dixon,Paul A. Trainor +7 more