S
Sadaf Khan
Researcher at Philippine Institute for Development Studies
Publications - 14
Citations - 2691
Sadaf Khan is an academic researcher from Philippine Institute for Development Studies. The author has contributed to research in topics: Senescence & Internal medicine. The author has an hindex of 4, co-authored 11 publications receiving 2012 citations. Previous affiliations of Sadaf Khan include University College London & Imperial College London.
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Journal ArticleDOI
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta,Ana Banito,Torsten Wuestefeld,Athena Georgilis,Peggy Janich,Jennifer P. Morton,Dimitris Athineos,Tae-Won Kang,Felix Lasitschka,Mindaugas Andrulis,Gloria Pascual,Kelly J. Morris,Sadaf Khan,Hong Jin,Gopuraja Dharmalingam,Ambrosius P. Snijders,Thomas L. Carroll,David Capper,Catrin Pritchard,Gareth J. Inman,Thomas Longerich,Owen J. Sansom,Salvador Aznar Benitah,Lars Zender,Jesús Gil +24 more
TL;DR: It is demonstrated that the SASP can cause paracrine senescence and impact on tumour suppression andSenescence in vivo and TGF-β ligands play a major role by regulating p15INK4b and p21CIP1.
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang,Tetyana Yevsa,Norman Woller,Lisa Hoenicke,Torsten Wuestefeld,Daniel Dauch,Anja Hohmeyer,Marcus Gereke,Ramona Rudalska,Anna Potapova,Marcus Iken,Mihael Vucur,Siegfried Weiss,Mathias Heikenwalder,Mathias Heikenwalder,Sadaf Khan,Jesús Gil,Dunja Bruder,Michael P. Manns,Peter Schirmacher,Frank Tacke,Michael Ott,Tom Luedde,Thomas Longerich,Stefan Kubicka,Lars Zender +25 more
TL;DR: It is shown that oncogene-induced senescence occurs in otherwise normal murine hepatocytes in vivo, and how the cellularsenescence program is involved in tumour immune surveillance by mounting specific immune responses against antigens expressed in pre-malignant senescent cells is illustrated.
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SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer
Luca Tordella,Sadaf Khan,Anja Hohmeyer,Ana Banito,Sabrina Klotz,Selina Raguz,Nadine Martin,Gopuraja Dhamarlingam,Thomas L. Carroll,José Mario González Meljem,Sumit Deswal,Juan Pedro Martinez-Barbera,Ramón García-Escudero,Johannes Zuber,Lars Zender,Jesús Gil +15 more
TL;DR: How knockdown of the SWI/SNF component ARID1B prevents OIS and cooperates with RAS to induce liver tumors is described and suggested that prosenescence therapies could be employed against SWI-SNF-mutated cancers.
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The impact of minority ethnic businesses on the spatial character of London’s high streets
TL;DR: This article examined the relationship between spatial accessibility, commercial diversity and minority ethnic business diversity in ten of London's high streets and found that streets with a significant MEB presence were more likely to benefit from commercial diversity, and that the sampled MEB units were measurably smaller in size.
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Knowledge and attitudes toward genetically modified (GM) food among health sciences university students in Karachi, Pakistan
TL;DR: In this paper, a cross-sectional survey-based study was conducted to explore the knowledge and attitude of health sciences university students toward GM foods, and a significant difference was found toward the acceptability of GM food in students from different health sciences disciplines.