L
Lars Zender
Researcher at German Cancer Research Center
Publications - 198
Citations - 25822
Lars Zender is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 58, co-authored 172 publications receiving 20884 citations. Previous affiliations of Lars Zender include Memorial Sloan Kettering Cancer Center & Howard Hughes Medical Institute.
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Journal ArticleDOI
A microRNA component of the p53 tumour suppressor network
Lin He,Xingyue He,Xingyue He,Lee P. Lim,Elisa de Stanchina,Elisa de Stanchina,Zhenyu Xuan,Yu Liang,Wen Xue,Lars Zender,Jill F. Magnus,Dana Ridzon,Aimee L. Jackson,Peter S. Linsley,Caifu Chen,Scott W. Lowe,Michele A. Cleary,Gregory J. Hannon +17 more
TL;DR: A family of miRNAs, miR-34a–c, whose expression reflected p53 status is described, whose encoded genes are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo.
Journal ArticleDOI
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue,Lars Zender,Cornelius Miething,Ross A. Dickins,Ross A. Dickins,Eva Hernando,Valery Krizhanovsky,Carlos Cordon-Cardo,Scott W. Lowe,Scott W. Lowe +9 more
TL;DR: It is indicated that p53 loss can be required for the maintenance of aggressive carcinomas, and illustrates how the cellular senescence program can act together with the innate immune system to potently limit tumour growth.
Journal ArticleDOI
Senescence of activated stellate cells limits liver fibrosis
Valery Krizhanovsky,Monica Yon,Monica Yon,Ross A. Dickins,Stephen Hearn,Janelle Simon,Janelle Simon,Cornelius Miething,Herman T. Yee,Lars Zender,Scott W. Lowe,Scott W. Lowe +11 more
TL;DR: In this paper, the authors show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis, derived primarily from activated hepatic stellate cells, which initially proliferate in response to liver damage and produce the extracellular matrix.
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta,Ana Banito,Torsten Wuestefeld,Athena Georgilis,Peggy Janich,Jennifer P. Morton,Dimitris Athineos,Tae-Won Kang,Felix Lasitschka,Mindaugas Andrulis,Gloria Pascual,Kelly J. Morris,Sadaf Khan,Hong Jin,Gopuraja Dharmalingam,Ambrosius P. Snijders,Thomas L. Carroll,David Capper,Catrin Pritchard,Gareth J. Inman,Thomas Longerich,Owen J. Sansom,Salvador Aznar Benitah,Lars Zender,Jesús Gil +24 more
TL;DR: It is demonstrated that the SASP can cause paracrine senescence and impact on tumour suppression andSenescence in vivo and TGF-β ligands play a major role by regulating p15INK4b and p21CIP1.
Journal ArticleDOI
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang,Tetyana Yevsa,Norman Woller,Lisa Hoenicke,Torsten Wuestefeld,Daniel Dauch,Anja Hohmeyer,Marcus Gereke,Ramona Rudalska,Anna Potapova,Marcus Iken,Mihael Vucur,Siegfried Weiss,Mathias Heikenwalder,Mathias Heikenwalder,Sadaf Khan,Jesús Gil,Dunja Bruder,Michael P. Manns,Peter Schirmacher,Frank Tacke,Michael Ott,Tom Luedde,Thomas Longerich,Stefan Kubicka,Lars Zender +25 more
TL;DR: It is shown that oncogene-induced senescence occurs in otherwise normal murine hepatocytes in vivo, and how the cellularsenescence program is involved in tumour immune surveillance by mounting specific immune responses against antigens expressed in pre-malignant senescent cells is illustrated.