T
Thomas Longerich
Researcher at Heidelberg University
Publications - 75
Citations - 5595
Thomas Longerich is an academic researcher from Heidelberg University. The author has contributed to research in topics: Fibrosis & Cirrhosis. The author has an hindex of 25, co-authored 75 publications receiving 4582 citations. Previous affiliations of Thomas Longerich include RWTH Aachen University & German Cancer Research Center.
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Journal ArticleDOI
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta,Ana Banito,Torsten Wuestefeld,Athena Georgilis,Peggy Janich,Jennifer P. Morton,Dimitris Athineos,Tae-Won Kang,Felix Lasitschka,Mindaugas Andrulis,Gloria Pascual,Kelly J. Morris,Sadaf Khan,Hong Jin,Gopuraja Dharmalingam,Ambrosius P. Snijders,Thomas L. Carroll,David Capper,Catrin Pritchard,Gareth J. Inman,Thomas Longerich,Owen J. Sansom,Salvador Aznar Benitah,Lars Zender,Jesús Gil +24 more
TL;DR: It is demonstrated that the SASP can cause paracrine senescence and impact on tumour suppression andSenescence in vivo and TGF-β ligands play a major role by regulating p15INK4b and p21CIP1.
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang,Tetyana Yevsa,Norman Woller,Lisa Hoenicke,Torsten Wuestefeld,Daniel Dauch,Anja Hohmeyer,Marcus Gereke,Ramona Rudalska,Anna Potapova,Marcus Iken,Mihael Vucur,Siegfried Weiss,Mathias Heikenwalder,Mathias Heikenwalder,Sadaf Khan,Jesús Gil,Dunja Bruder,Michael P. Manns,Peter Schirmacher,Frank Tacke,Michael Ott,Tom Luedde,Thomas Longerich,Stefan Kubicka,Lars Zender +25 more
TL;DR: It is shown that oncogene-induced senescence occurs in otherwise normal murine hepatocytes in vivo, and how the cellularsenescence program is involved in tumour immune surveillance by mounting specific immune responses against antigens expressed in pre-malignant senescent cells is illustrated.
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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment
Simon Reiss,Ilka Rebhan,Perdita Backes,Inés Romero-Brey,Holger Erfle,Petr Matula,Petr Matula,Petr Matula,Lars Kaderali,Marion Poenisch,Hagen Blankenburg,Marie Sophie Hiet,Thomas Longerich,Sarah Diehl,Fidel Ramírez,Tamas Balla,Karl Rohr,Karl Rohr,Artur Kaul,Sandra Bühler,Rainer Pepperkok,Thomas Lengauer,Mario Albrecht,Roland Eils,Roland Eils,Peter Schirmacher,Volker Lohmann,Ralf Bartenschlager +27 more
TL;DR: Analysis suggests that the direct activation of a lipid kinase by HCV NS5A contributes critically to the integrity of the membranous viral replication complex.
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Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
Karsten Wursthorn,Marc Lütgehetmann,Maura Dandri,Tassilo Volz,Peter Buggisch,Bernhard Zöllner,Thomas Longerich,Peter Schirmacher,Frauke Metzler,Myrga Zankel,C. Fischer,Graeme Currie,Carol L. Brosgart,Joerg Petersen +13 more
TL;DR: Combined therapy with peg‐IFN and ADV led to marked decreases in serum HBV‐DNA and intrahepatic cccDNA, which was significantly correlated with reduced HBsAg, suggesting the involvement of cytolytic mechanisms.
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Dysregulation of growth factor signaling in human hepatocellular carcinoma.
TL;DR: Dysregulation of pleiotropic growth factors, receptors and their downstream signaling pathway components represent a central protumorigenic principle in human hepatocarcinogenesis and several specific strategies are currently under development, which may improve the systemic treatment of human HCCs.