S
Sai-Yang Zhang
Researcher at Zhengzhou University
Publications - 58
Citations - 986
Sai-Yang Zhang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Chalcone & Apoptosis. The author has an hindex of 15, co-authored 57 publications receiving 638 citations. Previous affiliations of Sai-Yang Zhang include University of California, Irvine.
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Journal ArticleDOI
Molecular targeted approaches to cancer therapy and prevention using chalcones.
Danielle D. Jandial,Christopher A. Blair,Sai-Yang Zhang,Lauren S. Krill,Yan-Bing Zhang,Xiaolin Zi +5 more
TL;DR: This review is focused on molecular targets of chalcones and their potential implications in cancer prevention and therapy, which have the advantages of being inexpensive, easily available and less toxic.
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Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.
Xuejiao Tian,Sai-Yang Zhang,Hong-Min Liu,Yan-Bing Zhang,Christopher A. Blair,Dan Mercola,Paolo Sassone-Corsi,Xiaolin Zi +7 more
TL;DR: The study on global histone lysine methylation levels may also offer specific biomarkers for cancer detection, diagnosis and prognosis, as well as for genotoxic and non-genotoxic carcinogenic exposures and risk assessment.
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Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.
Dong-Jun Fu,Sai-Yang Zhang,Ying-Chao Liu,Zhang Li,Jun-Ju Liu,Jian Song,Ruo-Han Zhao,Feng Li,Hui-Hui Sun,Hong-Min Liu,Yan-Bing Zhang +10 more
TL;DR: A series of dithiocarbamate-chalcone derivates were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell lines (EC-109, SK-N-SH and MGC-803) as mentioned in this paper.
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A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.
Sai-Yang Zhang,Tingyu Li,Zhang Li,Xiangyu Wang,Hangqi Dong,Lili Li,Dong-Jun Fu,Yongchun Li,Xiaolin Zi,Hong-Min Liu,Yan-Bing Zhang,Hongde Xu,Cheng-Yun Jin +12 more
TL;DR: Results indicated that S17 is a leadbrominated chalcone derivate and deserves further investigation for prevention and treatment of gastric cancer.
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Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents
Sai-Yang Zhang,Dong-Jun Fu,Xiao-Xin Yue,Ying-Chao Liu,Jian Song,Hui-Hui Sun,Hong-Min Liu,Yan-Bing Zhang +7 more
TL;DR: A series of chalcone-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, EC-109 and MGC-803) as discussed by the authors.