Dan Mercola

TL;DR: The physical, chemical, and biological properties of insulin in the light of the atomic arrangement found in insulin crystals are reviewed in this paper, where the relation of the three-dimensional arrangement of the atoms in the molecule of 2-zinc insulin crystal to the solution properties of the insulin (particularly its states of aggregation), to the chemical reaction and chemical modification of the molecule, and to its primary biological activity is discussed.

TL;DR: Site-directed mutagenesis indicates that phosphorylation of these serines is essential for stimulation of c-Jun activity and for cooperation with Ha-ras in ocogenic transformation.

TL;DR: The PTEN tumour suppressor and pro-apoptotic gene is frequently mutated in human cancers and loss of Egr-1 expression could deregulate the PTEN gene and contribute to the radiation resistance of some cancer cells.

TL;DR: Results indicate that inhibition of TGF-beta expression significantly enhances tumor-cell immunogenicity and supports future clinical evaluation of T GF-beta antisense gene therapy for TGF -beta-expressing tumors.

TL;DR: It is shown that the same changes in c-Jun phosphorylation are elicited by a variety of transforming oncoproteins with distinct biochemical activities, including Ha-Ras, and Raf-1, which participate in a signal transduction pathway that leads to increased phosphorylated of serines 63 and 73 on c- Jun.