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Xiaolin Zi
Researcher at University of California, Irvine
Publications - 106
Citations - 5327
Xiaolin Zi is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Cancer & Wnt signaling pathway. The author has an hindex of 35, co-authored 94 publications receiving 4785 citations. Previous affiliations of Xiaolin Zi include Case Western Reserve University & University of California, Berkeley.
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Journal ArticleDOI
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
TL;DR: In breast cancer cell models that overexpress HER2/neu, an increased level of IGF-IR signaling appears to interfere with the action of trastuzumab, and strategies that target IGF- IR signaling may prevent or delay development of resistance to trastzumab.
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Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention
Xiaolin Zi,Rajesh Agarwal +1 more
TL;DR: Results suggest that silibinin could be a useful agent for the intervention of hormone-refractory human prostate cancer.
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Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
TL;DR: The results provide an example of resistance to an antineoplastic therapy that targets one tyrosine kinase receptor by increased signal transduction through an alternative pathway in a complex regulatory network.
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Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
Yi-Chao Zheng,Ying-Chao Duan,Jin-Lian Ma,Rui-Min Xu,Xiaolin Zi,Wen-Lei Lv,Meng-Meng Wang,Xian-Wei Ye,Shun Zhu,David L. Mobley,Yan-Yan Zhu,Jun-Wei Wang,Jinfeng Li,Zhi-Ru Wang,Wen Zhao,Hong-Min Liu +15 more
TL;DR: Five series of 1,2,3-triazole-dithiocarbamate hybrids were designed and synthesized and screened their inhibitory activity toward LSD1 and it was found that some of these compounds exhibited the most specific and robust inhibition of LSD1.
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Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness.
Xiaolin Zi,Yi Guo,Anne R. Simoneau,Christopher Hope,Jun Xie,Randall F. Holcombe,Bang H. Hoang +6 more
TL;DR: Examination of the biological effects of Frzb/sFRP3 on an androgen-independent prostate cancer cell model and transfection of PC-3 with a dominant-negative low-density lipoprotein receptor-related protein 5 (DN-LRP5) coreceptor suggested antitumor activity through the reversal of epithelial-to-mesenchymal transition and inhibition of MMP activities in a subset of prostate cancer.