Said A. Goueli

TL;DR: Surprisingly, inhibition of PKA catalytic activity had little effect on basal motility or motility stimulated by agents previously thought to work via PKA activation, and disruption of this interaction using cell-permeable anchoring inhibitor peptides may form the basis of a sperm-targeted contraceptive.

TL;DR: Experiments with conditioned media suggested that sustained activation of the ERK/MAP kinase pathway promoted the autocrine secretion of megakaryocytic lineage determination factors.

TL;DR: ADP-Glo is a novel bioluminescent, homogeneous assay for monitoring ADP producing biochemical reactions and thus it is an ideal assay for detecting enzyme activity using a wide variety of substrates and is applicable to not only primary and secondary screening but also kinase profiling.

TL;DR: Cell-permeable peptides developed based on a MEK1-derived peptide inhibited ERK-mediated activation of the transcriptional activity of ELK1 and did not have an inhibitory effect on the activity of two closely related classes of MAPKs, c-Jun amino-terminal kinase or p38 protein kinase.

TL;DR: The identification of a soluble protein whose tyrosine phosphorylation varies directly with motility and suggest that motility regulation may involve cross talk between PKA, calcium, and tyrosinesine kinase pathways is suggested.