Saif Khan

TL;DR: This article discusses the theory behind structure based and ligand based virtual screening processes, and discusses the principles and concepts of molecular docking, pharmacophores and other methods used in computer-aided drug design.

TL;DR: The present review explores the major types of multitudinous QS systems known in Gram-positive and Gram-negative bacteria and their roles in bacterial pathogenesis and drug resistance and highlights the recent advancements in discovery of promising new QS modulators and their efficiency in controlling infections caused by multidrug-resistant bacterial pathogens.

TL;DR: Artificial neural network (ANN) and genetic algorithm (GA) were applied to optimize the medium components for the production of actinomycinV from a newly isolated strain of Streptomyces triostinicus which is not reported to produce this class of antibiotics.

TL;DR: Nonpeptidyl inhibitor of caspase-3 identified in the present study expeditiously mimic the inhibitory action of the previously identified peptidyl inhibitors.

TL;DR: Marine microbes have the potential as upcoming and promising source of non-toxic compounds with sustainable anti-biofouling/anti- biofilm properties as they can produce substances that can inhibit not only the chemical components required for biofilm production but also the attachment, microorganism growth, and/or cell–cell communication.