Journal ArticleDOI
Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance.
Shafiul Haque,Faraz Ahmad,Sajad Ahmad Dar,Arshad Jawed,Raju K. Mandal,Mohd Wahid,Mohtashim Lohani,Saif Khan,Vineeta Singh,Naseem Akhter +9 more
TLDR
The present review explores the major types of multitudinous QS systems known in Gram-positive and Gram-negative bacteria and their roles in bacterial pathogenesis and drug resistance and highlights the recent advancements in discovery of promising new QS modulators and their efficiency in controlling infections caused by multidrug-resistant bacterial pathogens.About:
This article is published in Microbial Pathogenesis.The article was published on 2018-08-01. It has received 69 citations till now. The article focuses on the topics: Quorum sensing & Autoinducer.read more
Citations
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Journal ArticleDOI
The Concept of an Ideal Antibiotic: Implications for Drug Design.
TL;DR: The aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and the specific attributes of an ideal antibacterial drug.
Journal ArticleDOI
Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria.
Xihong Zhao,Zixuan Yu,Tian Ding +2 more
TL;DR: A new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance is discussed.
Journal ArticleDOI
The Continuing Threat of Methicillin-Resistant Staphylococcus aureus.
TL;DR: The aim of this review is to recap the history, the emergence, and clinical features of various MRSA infections, and to summarize the current advances regarding MRSA screening, typing, and therapeutic options for an audience of clinical microbiologists and infectious disease specialists.
Journal ArticleDOI
Non-traditional Antibacterial Therapeutic Options and Challenges.
TL;DR: This review summarizes the progress and setbacks of non-traditional approaches intent on circumventing bacterial drug resistance, which include targeting virulence via toxin production and virulence factor secretion, impeding bacterial adhesion to host cells and biofilm formation, interrupting or inhibiting bacterial communication, and downregulating virulence.
Journal ArticleDOI
Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens.
Osmel Fleitas Martínez,Osmel Fleitas Martínez,Pietra O. Rigueiras,Állan S. Pires,William F. Porto,William F. Porto,Osmar N. Silva,Cesar de la Fuente-Nunez,Octavio L. Franco,Octavio L. Franco,Octavio L. Franco +10 more
TL;DR: Various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition ofautoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis are reviewed.
References
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Journal ArticleDOI
Quorum Sensing in Bacteria
TL;DR: The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity.
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Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
TL;DR: This work reviews the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae and examines recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.
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Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis
TL;DR: It is suggested that the level of the signal receptor, LasR, is a critical trigger for quorum-activated gene expression, and acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture.
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Quorum Sensing in Staphylococci
TL;DR: It is suggested that agr autoactivation, unlike classical enzyme induction, can occur under suboptimal conditions and can distinguish self from non-self by inducing an exclusive and coordinated population wide response.
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Quorum sensing inhibitors: an overview.
TL;DR: This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections and it has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe.