Flora of Turkey and the East Aegean Islands.

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

A review on the dietary flavonoid kaempferol.

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in biological system via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in triazole-based derivatives as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired. Noticeably, a large number of triazole compounds as clinical drugs or candidates have been frequently employed for the treatment of various types of diseases, which have shown their large development value and wide potential as medicinal agents. This work systematically reviewed the recent researches and developments of the whole range of triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic, anticonvulsant, antiparasitic, antidiabetic, anti-obesitic, antihistaminic, anti-neuropathic, antihypertensive as well as other biological activities. The perspectives of the foreseeable future in the research and development of triazole-based compounds as medicinal drugs are also presented. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic triazole medicinal drugs.

Recent researches in triazole compounds as medicinal drugs.

1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

Flavonoids and their glycosides, including anthocyanins

Background: Metabolic syndrome is a constellation of various cardiovascular risk factors. Patients having Metabolic syndrome in association with ischemic heart disease tend to have more comorbidities and worse hospital course. Diabetes mellitus and other components of Metabolic syndrome adversely affects the microcirculation, myocardium, enlarges infarct size and patients are more prone to cardiac failure in those presenting with acute coronary event. Objective: To assess the frequency of metabolic syndrome among patients who sustained acute myocardial infarction without prior history of acute coronary events. Marerial and Methods: This was a crossectional descriptive study, conducted after ethical approval from institutional research board and ethical committee, at cardiology department of Qazi Hussain Ahmad medical complex Nowshera from 5th August 2020 st to 20th March 2021. Patients presenting with 1 ever episode of acute myocardial infarction were recruited into the study. NCEPATP‡V criteria was used to diagnose metabolic syndrome. 195 patients were recruited into the present study using WHO sample size calculator. Data analysis was done using SPSS version22. Results: Among 195 patients with acute MI, 58.5% (n=114) had metabolic syndrome. Frequency of metabolic syndrome increased with increasing age (57.8% vs 31.5% vs 10.5%; p=0.043). There was a significantly increased prevalence of hypertension (32.5% vs 67.5%; p=0.017), diabetes (35.9% vs 64.1%; p=0.027), elevated plasma triglycerides (30.7% vs 69.3%; p=0.047), low HDL cholesterol (36.8% vs 63.2%; p=0.003) and abdominal obesity (28.9% vs 71.1%; p=0.001) among the group of acute MI patients with metabolic syndrome as compared to those who had no metabolic syndrome. The difference in the frequency of MetS among male and females (59.6% vs 41.4%; p=0.56) was statistically insignificant. Conclusion: Among patients who had sustained acute MI, 58.5% (n=114) patients were found to have Metabolic Syndrome.

Frequency of Metabolic Syndrome among Patients who Sustained Acute Myocardial Infarction . CARDIOLOGY

Heavy metals are toxic to plants even at low concentration, resulting in growth and total biomass reduction. Present research was intended to assess the effect of induced chromium toxicity on growth and performance of wheat varieties (Ta-Habib and Sahar) extensively growing in Peshawar region, Khyber Pakhtunkhwa surrounded by industrial area, adding 2-4 ppm Cr+3 in the form of effluents to irrigation water. The study also focused on the enhancement effect of Hydroxyl benzoic acid (HBA) foliar spray under chromium toxicity wheat plant. Highest amplitude of agronomic characteristics, germination percentage and vigor index was observed in Ta-Habib indicated tolerant variety as compared to variety Sahar which has been proved by the hyper accumulation of Cr+3 in the mentioned variety. It was reported that treatments T1 (2ppm Cr+3) and T3 (4ppm Cr+3) showed adverse effects which were mitigated by the foliar application of Hydroxyl benzoic acid (HBA).
Keywords: Chromium toxicity; Foliar application; Hydroxyl benzoic acid; Wheat
http://dx.doi.org/10.19045/bspab.2020.90269

https://mail.thepab.org/index.php/journal/article/download/1613/989

32. Enhancement effect of Hydroxyl Benzoic Acid (HBA) foliar application on growth performance of Triticum aestivum L. (Wheat) under induced chromium toxicity

This study scrutinizes the role of AI literacy and ChatGPT-3 in enhancing critical reasoning and journalistic writing competencies among 50 third-term journalism students at Tajik National University. Given the escalating relevance of AI across sectors, including journalism, we aim to highlight the potential advantages of incorporating AI utilities in journalism pedagogy. We utilized a mixed- methods approach, comprising both quantitative and qualitative data collection techniques, for a comprehensive examination of the influence of AI literacy and ChatGPT-3 on student skill development.We gathered insights via surveys and interviews, revealing the impact of AI on learning outcomes. Our findings suggest a significant improvement in students' critical thinking and journalistic writing skills with ChatGPT-3 usage. The integration of AI tools in the classroom encourages in-depth analysis and collaboration, thereby enhancing students' writing skills. The results underline the importance of AI literacy in journalism education, preparing students for the rapidly transforming, AI-centric journalism industry.

Integration of Artificial Intelligence in Academia: A Case Study of Critical Teaching and Learning in Higher Education

Introduction: Transradial coronary intervention (CI) is frequently complicated by radial artery occlusion (RAO). The research has a variety of prevalence reports, and its indicators are not properly known. The purpose of this research was to analyze the frequency of RAO in diabetes mellitus patients 24 hours and one-month following CI. Methods: In this study, 1,350 participants (included 101 repeated operations after one month) who undergo 1,451 CI, were involved. Participants were assessed for RAO 24 hours and one month following CI. The major result was not identified in 47 participants (3.2%), thus, data on 1,303 participants were provided for analysis of the data. After receiving CI for 24 hours and a month, individuals with diabetic mellitus (DM) had their predictors of RAO examined using multiple regression analysis. Results: The total participants of 1,303 included 1,018 (78.1%) men and 285 (21.6%) women, with an average age of 57.6 years. The major result was not identified in 47 participants (3.2%), thus, data on 1,256 participants were provided for analysis of the data, in which 149 participants (12.3%) had the primary outcomes. There were 46 women (30.2%) in the RAO group. In the RAO cohort, DM was found in 58 (39.5%) individuals. 

Frequency of radial artery occlusion in patients with diabetes mellitus 24.hr and one month after coronary intervention

Phenolic contents are very important class of organic compounds with the ability to work as antioxidants. Based on this property, the medicinal plants containing high concentration of phenols can be used to treat various ailments associated to free radicals. During current investigation the phenolic contents of methanolic, ethyl acetate, chloroform and n-hexane extracts of Artemisia gmelinii, A. brevifolia, Menta royleana, M. longifolia, Datura stromonium and D. alba of Gilgit-Baltistan (G-B) origin were comparatively evaluated for phenolic contents (mg Gallic acid equivalents/Kg extract). The results showed that the non-polar fractions of D. stromonium and D. alba contains highest concentration of phenolic as compared to A. gmelinii, A. brevifolia, whereas, Mentha species were found to contain least total phenolic. The polar fractions of Artemisia species were also found as a rich source of phenolic. The results indicates that non-polar fractions of Datura species and polar fractions of Artemisia can be introduce as a rich source of natural phenolic/antioxidants for extraction and purification of individual ingredients.

Sajjad Ali

Papers

Frequency of Metabolic Syndrome among Patients who Sustained Acute Myocardial Infarction . CARDIOLOGY

32. Enhancement effect of Hydroxyl Benzoic Acid (HBA) foliar application on growth performance of Triticum aestivum L. (Wheat) under induced chromium toxicity

Integration of Artificial Intelligence in Academia: A Case Study of Critical Teaching and Learning in Higher Education

Frequency of radial artery occlusion in patients with diabetes mellitus 24.hr and one month after coronary intervention

Comparative analysis of total phenolic contents of some plant species of genus Artemisia, Mentha and Datura.