Sakari Vanharanta

TL;DR: A network of paracrine signals between carcinoma, myeloid, and endothelial cells that drives both processes in breast cancer is uncovered, and a mechanism linking chemoresistance and metastasis, with opportunities for intervention is provided.

TL;DR: Findings link TNC to pathways that support the fitness of metastasis-initiating breast cancer cells and highlight the relevance of TNC as an extracellular matrix protein of stem cell niches of the metastatic niche.

TL;DR: It is reported here that the risk allele G shows copy number increase during CRC development and provides evidence that the common CRC predisposition associated with 8q24 arises from enhanced responsiveness to Wnt signaling.

TL;DR: How cancer cells acquire the competence to colonize distant organs remains a central question in cancer biology and experimental work and high-resolution sequencing of human tissues have started to reveal the molecular and tumor evolutionary principles that underlie the emergence of metastatic traits.

TL;DR: Targeted therapy with BRAF, ALK or EGFR kinase inhibitors induces a complex network of secreted signals in drug-stressed human and mouse melanoma and human lung adenocarcinoma cells, which stimulates the outgrowth, dissemination and metastasis of drug-resistant cancer cell clones and supports the survival ofdrug-sensitive cancer cells.