I
Iina Niittymäki
Researcher at University of Helsinki
Publications - 14
Citations - 2531
Iina Niittymäki is an academic researcher from University of Helsinki. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 12, co-authored 14 publications receiving 2437 citations.
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Journal ArticleDOI
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more
TL;DR: Four previously unreported CRC risk loci are identified at 14q22.2, highlighting the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Sari Tuupanen,Mikko P. Turunen,Rainer Lehtonen,Outi Hallikas,Sakari Vanharanta,Sakari Vanharanta,Teemu Kivioja,Mikael Björklund,Gong-Hong Wei,Jian Yan,Iina Niittymäki,Jukka-Pekka Mecklin,Heikki Järvinen,Ari Ristimäki,Ari Ristimäki,Mariachiara Di-Bernardo,Phil East,Luis G. Carvajal-Carmona,Richard S. Houlston,Ian Tomlinson,Kimmo Palin,Kimmo Palin,Esko Ukkonen,Auli Karhu,Jussi Taipale,Lauri A. Aaltonen +25 more
TL;DR: It is reported here that the risk allele G shows copy number increase during CRC development and provides evidence that the common CRC predisposition associated with 8q24 arises from enhanced responsiveness to Wnt signaling.
Journal ArticleDOI
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Richard S. Houlston,Jeremy Peter Cheadle,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Sarah L. Spain,Peter Broderick,Enric Domingo,Susan M. Farrington,James G. D. Prendergast,Alan M. Pittman,Evi Theodoratou,Christopher Smith,Bianca Olver,Axel Walther,Rebecca A. Barnetson,Michael Churchman,Emma Jaeger,Steven Penegar,Ella Barclay,Lynn Martin,Maggie Gorman,Rachel Mager,Elaine C. Johnstone,Rachel Midgley,Iina Niittymäki,Sari Tuupanen,James Colley,Shelley Idziaszczyk,Huw Thomas,Anneke Lucassen,D. Gareth Evans,Eamonn R. Maher,Tim Maughan,Antigone S. Dimas,Antigone S. Dimas,Emmanouil T. Dermitzakis,Jean-Baptiste Cazier,Lauri A. Aaltonen,Paul D.P. Pharoah,David J. Kerr,David J. Kerr,Luis G. Carvajal-Carmona,Harry Campbell,Malcolm G. Dunlop,Ian Tomlinson +46 more
TL;DR: A meta-analysis of three GWAS from the UK provides evidence that additional CRC-associated variants of similar effect size remain to be discovered and identifies four new CRC risk loci.
Journal ArticleDOI
Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals
Malcolm G. Dunlop,Albert Tenesa,Susan M. Farrington,Stephane Ballereau,David H. Brewster,Thibaud Koessler,Paul D.P. Pharoah,Clemens Schafmayer,Jochen Hampe,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Susanna von Holst,Simone Picelli,Annika Lindblom,Mark A. Jenkins,John L. Hopper,Graham Casey,David Duggan,Polly A. Newcomb,Anna Abulí,Xavier Bessa,Clara Ruiz-Ponte,Sergi Castellví-Bel,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Brent W. Zanke,Thomas J. Hudson,Steven Gallinger,Ella Barclay,Lynn Martin,Maggie Gorman,Luis G. Carvajal-Carmona,Axel Walther,David J. Kerr,Steven J. Lubbe,Peter Broderick,Ian Chandler,Alan M. Pittman,Steven Penegar,Harry Campbell,Ian Tomlinson,Richard S. Houlston +45 more
TL;DR: Genotype data provide additional information that complements age, gender and FH as risk factors, but individualised genetic risk prediction is not currently feasible, the modelling exercise suggests public health potential since it is possible to stratify the population into CRC risk categories, thereby informing targeted prevention and surveillance.