S
Saksham Gupta
Researcher at Brigham and Women's Hospital
Publications - 74
Citations - 2865
Saksham Gupta is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Craniotomy. The author has an hindex of 13, co-authored 54 publications receiving 1770 citations. Previous affiliations of Saksham Gupta include Johns Hopkins University & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Estimating the global incidence of traumatic brain injury
Michael C. Dewan,Abbas Rattani,Saksham Gupta,Ronnie E. Baticulon,Ya-Ching Hung,Maria Punchak,Amit Agrawal,Amos Olufemi Adeleye,Mark G. Shrime,Andres M. Rubiano,Jeffrey V. Rosenfeld,Kee B. Park +11 more
TL;DR: The case burden of TBI across World Health Organization regions and World Bank income groups was sought to promote advocacy, understanding, and targeted intervention, and study quality was higher in the high-income countries (HICs) than in the low- and middle- Income countries (LMICs).
Journal ArticleDOI
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Ke Zhang,Christopher J. Donnelly,Aaron R. Haeusler,Jonathan C. Grima,James B. Machamer,Peter Steinwald,Elizabeth L. Daley,Sean J. Miller,Kathleen M. Cunningham,Svetlana Vidensky,Saksham Gupta,Michael A. Thomas,Ingie Hong,Shu Ling Chiu,Richard L. Huganir,Lyle W. Ostrow,Michael J. Matunis,Jiou Wang,Rita Sattler,Thomas E. Lloyd,Jeffrey D. Rothstein +20 more
TL;DR: Nuclear import is impaired as a result of HRE expression in the fly model and in C9orf72 iPSC-derived neurons, and these deficits are rescued by small molecules and antisense oligonucleotides targeting the HRE G-quadruplexes.
Journal ArticleDOI
Radiographic prediction of meningioma grade by semantic and radiomic features
Thibaud P. Coroller,Wenya Linda Bi,Wenya Linda Bi,Elizabeth Huynh,Malak Abedalthagafi,Malak Abedalthagafi,Ayal A. Aizer,Noah F. Greenwald,Chintan Parmar,Vivek Narayan,Winona W. Wu,Samuel Miranda de Moura,Saksham Gupta,Rameen Beroukhim,Patrick Y. Wen,Ossama Al-Mefty,Ian F. Dunn,Sandro Santagata,Brian M. Alexander,Raymond Y. Huang,Hugo J.W.L. Aerts +20 more
TL;DR: A strong association between imaging features of meningioma and histopathologic grade is found, with ready application to clinical management, and combining qualitative and quantitative radiographic features significantly improved classification power.
Journal ArticleDOI
Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes
Christopher Smith,Onur Kilic,Paula Schiapparelli,Hugo Guerrero-Cazares,Deok Ho Kim,Neda I. Sedora-Roman,Saksham Gupta,Thomas O’Donnell,Kaisorn L. Chaichana,Fausto J. Rodriguez,Sara Abbadi,JinSeok Park,Alfredo Quiñones-Hinojosa,Andre Levchenko +13 more
TL;DR: A method is described that allows time-resolved studies of primary cell migration with single-cell resolution on a fibrillar surface that closely mimics in vivo 3D migration.
Journal ArticleDOI
Pre-Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer
Christopher Smith,Kaisorn L. Chaichana,Young M. Lee,Benjamin Lin,Kevin M. Stanko,Thomas O’Donnell,Saksham Gupta,Sagar R. Shah,Joanne Wang,Olindi Wijesekera,Michael Delannoy,Andre Levchenko,Alfredo Quiñones-Hinojosa +12 more
TL;DR: A reproducible, comprehensive, cell culture‐based approach to enhance human adipose‐derived MSC (hAMSC) engraftment to brain tumors and a novel method to enhance stem cell homing to gliomas and, potentially, other neurological disorders is provided.