S
Sakshi Mishra
Researcher at Central Drug Research Institute
Publications - 23
Citations - 637
Sakshi Mishra is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Oxidative stress & Inflammation. The author has an hindex of 10, co-authored 20 publications receiving 459 citations. Previous affiliations of Sakshi Mishra include Indian Institute of Toxicology Research & Banaras Hindu University.
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Journal ArticleDOI
Role of oxidative stress in Deoxynivalenol induced toxicity
TL;DR: The evidence for induction of an oxidative stress response resulting from DON exposure has been more focused on in vitro models and is relatively lacking in in vivo studies, so more emphasis should be laid on in vivo investigations with doses that are commonly encountered in food products.
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Global occurrence of deoxynivalenol in food commodities and exposure risk assessment in humans in the last decade: a survey.
TL;DR: The present review indicates that the current exposure levels of DON might pose a health risk for the consumers, especially in growing children, necessitating to take vigilant steps to guarantee food safety.
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Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats.
TL;DR: Fr-CHCl(3) of Xylocarpus granatum was found to possess anti-ulcerogenic activity which might be due to its anti-secretory activity and subsequent strengthening of the defensive mechanism, and could act as a potent therapeutic agent against peptic ulcer disease.
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Occurrence of deoxynivalenol in cereals and exposure risk assessment in Indian population
Sakshi Mishra,Sakshi Mishra,Kausar M. Ansari,Premendra D. Dwivedi,Haushila Prasad Pandey,Mukul Das +5 more
TL;DR: Since DON levels have been set for wheat only there is a need to formulate regulatory standards for other cereals so as to reduce the exposure risk to DON to suggest the possibility of DON exposure to humans.
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Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway.
Sakshi Mishra,Sakshi Mishra,Anurag Tripathi,Bhushan P. Chaudhari,Premendra D. Dwivedi,Haushila Prasad Pandey,Mukul Das +6 more
TL;DR: The results suggest that DON induced cell proliferation in mouse skin is through the activation of MAPK signaling pathway involving transcription factors NFκB and AP-1, further leading to transcriptional activation of downstream target proteins c-fos, c-jun, cyclin D1, iNOS and COX-2 which might be responsible for its inflammatory potential.