S
Sakshi Singh
Researcher at Banaras Hindu University
Publications - 39
Citations - 285
Sakshi Singh is an academic researcher from Banaras Hindu University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 30 publications receiving 142 citations. Previous affiliations of Sakshi Singh include Centre for Cellular and Molecular Biology & Utrecht University.
Papers
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Journal ArticleDOI
Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup
Sakshi Singh,Ashish Singh,Raja Rajkumar,Katakam Sampath Kumar,Subburaj Kadarkarai Samy,Sheikh Nizamuddin,Amita Singh,Shahnawaz Ahmed Sheikh,Vidyadhari Peddada,Vinee Khanna,Pandichelvam Veeraiah,Aridaman Pandit,Gyaneshwer Chaubey,Lalji Singh,Kumarasamy Thangaraj +14 more
TL;DR: Contrary to the widely accepted elite dominance model, a substantial presence of J2a-M410 and J2b-M102 haplogroups in both caste and tribal populations of India is found.
Journal ArticleDOI
IL-4 Haplotype -590T, -34T and Intron-3 VNTR R2 Is Associated with Reduced Malaria Risk among Ancestral Indian Tribal Populations
Aditya Nath Jha,Vipin Kumar Singh,Namrata Kumari,Ashish Singh,Justin S. Antony,Hoang Van Tong,Sakshi Singh,S. S. Pati,Pradeep Kumar Patra,Rajender Singh,Nguyen Linh Toan,Le Huu Song,Amal Assaf,Iara Jose Messias Reason,Thirumalaisamy P. Velavan,Lalji Singh,Lalji Singh,Kumarasamy Thangaraj +17 more
TL;DR: The study suggests that the IL-4 polymorphisms regulate host susceptibility to malaria and disease progression, which gives protection against malaria, is high among ATPs.
Journal ArticleDOI
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Michael J. Munson,Michael J. Munson,Benan John Mathai,Matthew Yoke Wui Ng,Laura Trachsel-Moncho,Laura R. de la Ballina,Sebastian W. Schultz,Yahyah Aman,Alf Håkon Lystad,Sakshi Singh,Sachin Kumar Singh,Sachin Kumar Singh,Jørgen Wesche,Jørgen Wesche,Evandro Fei Fang,Anne Simonsen +15 more
TL;DR: In this paper, the authors identify cyclin G-associated kinase (GAK) and protein Kinase C Delta (PRKCD) as regulators of PRKN-independent mitophagy, with both being dispensable for PRKNdependent mitophagia and starvation-induced autophagy.
Journal ArticleDOI
NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.
Wout J. Weuring,Sakshi Singh,Linda Volkers,Martin B. Rook,Ruben van 't Slot,Marjolein Bosma,Marco Inserra,Irina Vetter,Nanda M. Verhoeven-Duif,Kees P.J. Braun,Mirko Rivara,Bobby P. C. Koeleman +11 more
TL;DR: Results show that selective inhibition of NaV1.6 could be just as efficient as selective activation of Nav1.1 or NaV 1.6 and these approaches could prove to be novel potential treatment strategies for Dravet syndrome and other (genetic) epilepsies.
Posted ContentDOI
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Michael J. Munson,Benan John Mathai,Laura Trachsel,Matthew Yoke Wui Ng,Laura R. de la Ballina,Sebastian W. Schultz,Yahyah Aman,Alf Håkon Lystad,Sakshi Singh,Sachin Kumar Singh,Jørgen Wesche,Evandro Fei Fang,Anne Simonsen +12 more
TL;DR: It is demonstrated that the kinase activity of both GAK and PRKCD are required for efficient mitophagy in vitro, thatPRKCD is present on mitochondria, and that PRK CD is required for ULK1/ATG13 recruitment to early autophagic structures.