S
Sally Spendiff
Researcher at Children's Hospital of Eastern Ontario
Publications - 32
Citations - 608
Sally Spendiff is an academic researcher from Children's Hospital of Eastern Ontario. The author has contributed to research in topics: Medicine & Neuromuscular junction. The author has an hindex of 12, co-authored 23 publications receiving 419 citations. Previous affiliations of Sally Spendiff include McGill University Health Centre & Ottawa Hospital.
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Journal ArticleDOI
Failed reinnervation in aging skeletal muscle
Sudhakar Aare,Sudhakar Aare,Sally Spendiff,Sally Spendiff,Madhusudanarao Vuda,Madhusudanarao Vuda,Daren Elkrief,Daren Elkrief,Anna Perez,Qinghua Wu,Qinghua Wu,Dominique Mayaki,Sabah N. A. Hussain,Stefan Hettwer,Russell T. Hepple,Russell T. Hepple +15 more
TL;DR: The hypothesis that the accumulation of denervated fibers with aging is due to failed reinnervation and that this may be affected by a limited neurotrophin response that mediates axonal sprouting following denervation is supported.
Journal ArticleDOI
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle
Gilles Gouspillou,Celena Scheede-Bergdahl,Sally Spendiff,Madhusudanarao Vuda,Brian Meehan,Heather Mlynarski,Elodie Archer-Lahlou,Nicolas Sgarioto,Fennigje M. Purves-Smith,Yana Konokhova,Janusz Rak,Stéphanie Chevalier,Tanja Taivassalo,Russell T. Hepple,R. Thomas Jagoe +14 more
TL;DR: A novel pattern of chemotherapy-induced mitochondrial dysfunction in skeletal muscle that persists because of an acquired defect in mitophagy signaling is suggested and could explain the observed functional impairments in adult survivors of childhood ALL and may be relevant to long-term survivors of other cancers treated with similar regimes.
Journal ArticleDOI
Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women
Vita Sonjak,Vita Sonjak,Kathryn J Jacob,José A. Morais,José A. Morais,Marie Rivera-Zengotita,Sally Spendiff,Carole S L Spake,Tanja Taivassalo,Stéphanie Chevalier,Stéphanie Chevalier,Russell T. Hepple +11 more
TL;DR: It is shown that prefrail/frail elderly women exhibited marked features of muscle denervation, whereas world class octogenarian female master athletes showed attenuated indices of denervation and greater reinnervation capacity.
Journal ArticleDOI
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.
Sally Spendiff,Sally Spendiff,Madhusudanarao Vuda,Madhusudanarao Vuda,Gilles Gouspillou,Gilles Gouspillou,Sudhakar Aare,Sudhakar Aare,Anna Perez,José A. Morais,R.T. Jagoe,Marie-Eve Filion,Robin Glicksman,Sophia Kapchinsky,Norah J. MacMillan,Charlotte H. Pion,Mylène Aubertin-Leheudre,Stefan Hettwer,José A. Correa,Tanja Taivassalo,Russell T. Hepple,Russell T. Hepple +21 more
TL;DR: The role of denervation in modulating mitochondrial function in ageing muscle is unknown as mentioned in this paper, however, it has been shown that increased sensitivity to apoptosis initiation occurs prior to evidence of persistent denervation and is thus a primary mitochondrial defect in aging muscle worthy of therapeutic targeting.
Journal ArticleDOI
Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes
Geoffrey A. Power,Fabio C. Minozzo,Sally Spendiff,Marie-Eve Filion,Yana Konokhova,Maddy F. Purves-Smith,Charlotte H. Pion,Mylène Aubertin-Leheudre,José A. Morais,Walter Herzog,Russell T. Hepple,Tanja Taivassalo,Dilson E. Rassier +12 more
TL;DR: The slower Vo in both old groups relative to young, coupled with a similarly reduced ktr, suggests impaired cross-bridge kinetics are responsible for impaired single fiber contractile properties with aging, and challenges the widely accepted resilience of slow type fibers to cellular aging.