Salvador Fortaner

TL;DR: Thinking in terms of validity principles will broaden the applicability of the validation process to a variety of tests and procedures, including the generation of new tests, new technologies, computer-based models, and expert systems.

TL;DR: In this paper, the importance of beverages as a dietary factor in influencing the establishment of trace element reference values in body fluids and tissues of the general population, elements were determined in table wines, mineral waters, beers, ready-to-drink-infusion of tea and instant coffees consumed by Italians.

TL;DR: The results indicate that some compounds belonging to both the organic and inorganic species were able to induce significant increases in the tail moment, the parameter used to determine genotoxicity.

TL;DR: Steering groups formed by ECVAM senior staff, and complemented with external experts, will carry out the project management and will coordinate the various inputs.

TL;DR: Findings suggest that MN induction is due both to a clastogenic and an aneuploidogenic mechanism, and highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts.