Laura Gribaldo

TL;DR: Thinking in terms of validity principles will broaden the applicability of the validation process to a variety of tests and procedures, including the generation of new tests, new technologies, computer-based models, and expert systems.

TL;DR: An international blind trial designed to apply a predictive model to calculate the human maximum tolerated dose (MTD) for 20 drugs and confirms that the model can be considered scientifically validated in this study, suggesting promising applications to other areas of research in developing validated hematotoxicological in vitro methods.

TL;DR: Results showed that the assay is linear under SOP conditions, and that the in vitro endpoints used by the clinical prediction model of neutropenia are highly reproducible within and between laboratories.

TL;DR: It was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways, and the ECETOC workshop provided important incentives towards achieving this goal.

TL;DR: Results support the idea that rotenone can potentially be a developmental neurotoxicant and show a possible link between previously shown effects on neurite outgrowth and presently observed effects on Ca2+ reabsorption, synaptogenesis and PPAR pathway disruption.