Marlies Halder

TL;DR: The goal was to review the state of the science regarding the investigation of fish embryonic tests, pain and distress in fish, emerging approaches utilizing fish embryos, and the use of fish embryo toxicity test data in various types of environmental assessments.

TL;DR: Thinking in terms of validity principles will broaden the applicability of the validation process to a variety of tests and procedures, including the generation of new tests, new technologies, computer-based models, and expert systems.

TL;DR: This is the report of the forty-seventh of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM), held in Angera, Italy, on 22–24 October 2001, under the co-chairmanship of Argelia Castaño and Helmut Segner.

TL;DR: The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 different concentrations in 3 independent runs in at least 3 laboratories, showing that the ZfET is a robust method with a good intra- and inter-laboratory reproducible for most chemicals and laboratories.

TL;DR: How the AOP concept can be used to guide research aimed at improving both understanding of chronic toxicity as well as epigenetic and transgenerational effects of chemicals, and the ability to predict adverse outcomes is explored.