Salvatore Pepe

TL;DR: Metabolic therapy involves the administration of a substance normally found in the body to enhance a metabolic reaction within the cell as mentioned in this paper, which may be achieved in two ways: first, for some systems a substance can be given to achieve greater than normal levels in the human body so as to drive an enzymic reaction in a preferred direction.

TL;DR: Therapy with stavudine results in impaired mitochondrial function in CD4+PBLs that does not appear to be due to reduced mitochondrial volume or DNA content and cannot be attributed to infection with HIV.

TL;DR: In this paper, a small molecule inhibitor of p38 mitogen-activated protein kinase (p38 MAPK) was used in rat heart and lungs after experimentally induced brain death.

TL;DR: The impact of Coenzyme Q10 pretreatment in a model of mild and severe lung injury is studied to study the protective effect in the lung of this potent antioxidant and cellular energizer.

TL;DR: A 52-year-old man, who in 1985 developed ragged-red fibre myopathy 14 years after diagnosis of HIV infection while on effective ZDV-based combination antiretroviral therapy (ART), was treated with the mitochondrial anti-oxidant coenzyme Q10 and made an excellent recovery, potentially allowing continuation of antiviral treatments including ZdV.