Salvatore Pepe

TL;DR: It is demonstrated that chronic in vivo exposure to elevated levels of intra-cardiac Ang II is associated with significant contractile abnormalities evident in the ex vivo intact heart and suggested that endogenous overproduction of cardiac Ang II, independent of changes in blood pressure, is sufficient to induce ventricular remodelling that culminates in impaired cardiac function which may precede failure.

TL;DR: In patients with cyanotic heart disease, a high proportion of proteins are in phosphorylated form, and RIPC does not further enhance phosphorylation protein signaling in myocardium or circulating leukocytes in children undergoing ToF repair.

TL;DR: Current knowledge and recent findings regarding physiological and pathophysiological modulation of the heart and vessels by the opioid receptor system are highlighted and discussed.

TL;DR: Current data on the early life origins of atherosclerosis and cardiovascular disease, with particular focus on perinatal inflammation is summarised, suggesting an association between chorioamnionitis and cardiac and vascular dysfunction.

TL;DR: The risk of excess Ca2+ loading within the senescent heart can potentially be reduced by gene therapy to restoreCa2+ regulatory proteins, by diet to reverse the membrane omega 6:omega 3 PUFA imbalance, or by antioxidants.