S
Salvatore Pepe
Researcher at Royal Children's Hospital
Publications - 131
Citations - 10554
Salvatore Pepe is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 39, co-authored 128 publications receiving 9804 citations. Previous affiliations of Salvatore Pepe include University of Adelaide & Alfred Hospital.
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Journal ArticleDOI
Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.
Franklin L. Rosenfeldt,Francis Miller,Phillip Nagley,Anthony Hadj,Silvana Marasco,Deahne Quick,Freya L. Sheeran,Michelle Wowk,Salvatore Pepe +8 more
TL;DR: It is concluded that the aging heart has a diminished capacity to recover from stress that is not readily predictable by cardiac content of intact mitochondrial DNA and that this recovery can be improved by metabolic therapy combined with physical exercise and mental stress reduction.
Journal ArticleDOI
A maintained afterload model of ischemia in erythrocyte-perfused isolated working hearts.
Salvatore Pepe,Peter L McLennan +1 more
TL;DR: The maintained afterload model of ischemia is a simple enhancement of the isolated working heart permitting a separation of workload and coronary perfusion pressure variables and provides greater control over and direct monitoring of experimental ischemic events in progress.
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Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice.
Catherine E. Huggins,Claire L. Curl,Ruchi Patel,Peter L McLennan,Mandy L. Theiss,Thierry Pedrazzini,Salvatore Pepe,Salvatore Pepe,Lea M.D. Delbridge +8 more
TL;DR: A lack of cardioprotective effect of dietary FO in females is indicated by assessment of mechanical and arrhythmic activity postischemia in a murine ex vivo heart model.
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Weighing Up Fish and Omega-3 PUFA Advice with Accurate, Balanced Scales: Stringent Controls and Measures Required for Clinical Trials.
Peter L McLennan,Salvatore Pepe +1 more
TL;DR: In this update of the 2008 National Heart Foundation of Australia (NHF) recommendations on clinical evidence for omega-3 PUFA in prevention and treatment of cardiovascular disease, Nestel et al. conclude that whilst there are clear benefits of eating fish, there is no additional support to recommend the use of refined fish oil supplements.