S
Salvatore Pepe
Researcher at Royal Children's Hospital
Publications - 131
Citations - 10554
Salvatore Pepe is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 39, co-authored 128 publications receiving 9804 citations. Previous affiliations of Salvatore Pepe include University of Adelaide & Alfred Hospital.
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Journal ArticleDOI
The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms
TL;DR: There is the first definitive evidence that resveratrol specifically protects cardiomyocytes from I-R injury via a combination of suppression of superoxide levels and activation of potassium channels, and this protection is apparent whether resver atrol is present for the full duration of the insult or only on recovery.
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Energy deficiency in the failing heart: Linking increased reactive oxygen species and disruption of oxidative phosphorylation rate
Freya L. Sheeran,Salvatore Pepe +1 more
TL;DR: Some of the mounting evidence indicating that augmented superoxide, related reactive oxygen species and other free radicals contribute to the oxidative stress evident during the progression of heart failure are highlighted.
Journal ArticleDOI
Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium
Freya L. Sheeran,Jan Rydström,Mikhail I. Shakhparonov,Nikolay B. Pestov,Salvatore Pepe,Salvatore Pepe +5 more
TL;DR: In the failing human heart a partial loss of Nnt activity adversely impacts NADPH-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense, exacerbate oxidative damage to cellular proteins.
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Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes.
TL;DR: Diet rich in omega-3 PUFA reverses the age-associated membrane omega- 3:omega-6 PUFA imbalance, and dysfunctional Ca2+ metabolism, facilitating increased efficiency of mitochondrial energy production and improved tolerance of ischemia and reperfusion.
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‘Cross Talk’ Between Opioid Peptide and Adrenergic Receptor Signaling in Isolated Rat Heart
TL;DR: Potent, inhibitory "cross talk" between delta-OPR and beta1-AR signaling pathways occurs via a PTX-sensitive G(i/o) protein involved in adenylyl cyclase inhibition in rat heart.