T
Thierry Pedrazzini
Researcher at University of Lausanne
Publications - 138
Citations - 12790
Thierry Pedrazzini is an academic researcher from University of Lausanne. The author has contributed to research in topics: Angiotensin II & Receptor. The author has an hindex of 53, co-authored 129 publications receiving 11717 citations. Previous affiliations of Thierry Pedrazzini include Université libre de Bruxelles & Goethe University Frankfurt.
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Journal ArticleDOI
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice
Catherine Ledent,Olga Valverde,G Cossu,François Petitet,Jean-François Aubert,Françoise Beslot,Georg Andrees Bohme,Assunta Imperato,Thierry Pedrazzini,Bernard P. Roques,Gilbert Vassart,Walter Fratta,Marc Parmentier +12 more
TL;DR: Observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
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Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
Catherine Ledent,Jean-Marie Vaugeois,Serge N. Schiffmann,Thierry Pedrazzini,Malika El Yacoubi,Jean-Jacques Vanderhaeghen,Jean Costentin,John K. Heath,Gilbert Vassart,Marc Parmentier +9 more
TL;DR: It was found that A2aR-knockout mice were viable and bred normally, and male mice were much more aggressive towards intruders, whereas caffeine, which normally stimulates exploratory behaviour, became a depressant of exploratory activity.
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Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
Hervé Duplain,Rémy Burcelin,Claudio Sartori,Stéphane Cook,Marc Egli,Mattia Lepori,Peter Vollenweider,Thierry Pedrazzini,Pascal Nicod,Bernard Thorens,Urs Scherrer +10 more
TL;DR: Results indicate that eNOS is important for the control not only of arterial pressure but also of glucose and lipid homeostasis, and indicate that a single gene defect, eNos deficiency, may represent the link between metabolic and cardiovascular disease.
Journal Article
Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.
R C Budd,Jean Charles Cerottini,C Horvath,Claude Bron,Thierry Pedrazzini,R C Howe,H R MacDonald +6 more
TL;DR: Ex expression of Pgp-1 among peripheral T cells is an important differentiation marker for identifying antigen-stimulated memory T cells and a model consistent with all of these data proposes that mature thymocytes lacking surface P gp-1 upon emigration to the periphery acquire its expression at the time of primary antigenic stimulation.
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Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
Thierry Pedrazzini,Josiane Seydoux,Pierre Künstner,Jean-François Aubert,Eric Grouzmann,Friedrich Beermann,Hans R. Brunner +6 more
TL;DR: The results demonstrate the importance of NPY Y1 receptors in NPY-mediated cardiovascular response and in the regulation of body weight through central control of energy expenditure and are also indicative of a role for the Y1 receptor in the control of food intake.