P
Pat P. Ongusaha
Researcher at Harvard University
Publications - 28
Citations - 2890
Pat P. Ongusaha is an academic researcher from Harvard University. The author has contributed to research in topics: Kinase & Apoptosis. The author has an hindex of 22, co-authored 28 publications receiving 2719 citations. Previous affiliations of Pat P. Ongusaha include University of Birmingham & Brigham and Women's Hospital.
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Journal ArticleDOI
Phosphoinositide signalling links O -GlcNAc transferase to insulin resistance
Xiaoyong Yang,Pat P. Ongusaha,Philip D.G. Miles,Joyce C. Havstad,Fengxue Zhang,W. Venus So,Jeffrey E. Kudlow,Robert H. Michell,Jerrold M. Olefsky,Seth J. Field,Ronald M. Evans +10 more
TL;DR: It is shown that O-GlcNAc transferase (OGT) harbours a previously unrecognized type of phosphoinositide-binding domain, which underscores the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes.
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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
Hank H. Qi,Hank H. Qi,Madathia Sarkissian,Madathia Sarkissian,Gangqing Hu,Zhibin Wang,Arindam Bhattacharjee,D. Benjamin Gordon,Michelle Gonzales,Fei Lan,Fei Lan,Pat P. Ongusaha,Maite Huarte,Maite Huarte,Nasser K. Yaghi,Nasser K. Yaghi,Hui-Jun Lim,Hui-Jun Lim,Benjamin A. Garcia,Leonardo Brizuela,Keji Zhao,Thomas M. Roberts,Yang Shi,Yang Shi +23 more
TL;DR: Genetic and molecular evidence supports a model whereby PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways.
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Prolyl 4-hydroxylation regulates Argonaute 2 stability
Hank H. Qi,Pat P. Ongusaha,Johanna Myllyharju,Dongmei Cheng,Outi Pakkanen,Yujiang Shi,Sam W. Lee,Junmin Peng,Yang Shi +8 more
TL;DR: Hydroxylation is identified as a post-translational modification important for Ago2 stability and effective RNA interference.
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HB-EGF is a potent inducer of tumor growth and angiogenesis.
Pat P. Ongusaha,Jennifer C. Kwak,Andrew J. Zwible,Salvador Macip,Shigeki Higashiyama,Naoyuki Taniguchi,Li Fang,Sam W. Lee +7 more
TL;DR: Findings establish s-HB-EGF as a potent inducer of tumor growth and angiogenesis and suggest that therapeutic intervention aimed at the inhibition of s- HB- EGF functions may be useful in cancer treatment.
Journal ArticleDOI
P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.
Jeong A. Han,Jong Il Kim,Pat P. Ongusaha,Daniel H. Hwang,Leslie R. Ballou,Alka Mahale,Stuart A. Aaronson,Sam W. Lee +7 more
TL;DR: Results demonstrate that Cox‐2 is induced by p53‐mediated activation of the Ras/Raf/ERK cascade, counteracting p 53‐mediated apoptosis, and this anti‐apoptosis effect may be a mechanism to abate cellular stresses associated with p53 induction.