S
Samantha Donsante
Researcher at Sapienza University of Rome
Publications - 22
Citations - 161
Samantha Donsante is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 9 publications receiving 52 citations.
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Journal ArticleDOI
RANKL Inhibition in Fibrous Dysplasia of Bone: A Preclinical Study in a Mouse Model of the Human Disease
Biagio Palmisano,Emanuela Spica,Cristina Remoli,Rossella Labella,Annamaria Di Filippo,Samantha Donsante,Fabiano Bini,Domenico Raimondo,Franco Marinozzi,Alan Boyde,Pamela Gehron Robey,Alessandro Corsi,Mara Riminucci +12 more
TL;DR: The results show that the anti‐RANKL antibody significantly affected the bone pathology and natural history of FD in the mouse, suggesting that RANKL inhibition may be an effective therapeutic option for FD patients.
Journal ArticleDOI
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Alice Pievani,Benedetto Sacchetti,Alessandro Corsi,Benedetta Rambaldi,Samantha Donsante,Valeria Scagliotti,Patrizia Vergani,Cristina Remoli,Andrea Biondi,Pamela Gehron Robey,Mara Riminucci,Marta Serafini +11 more
TL;DR: It is indicated that CB-BFs are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete HSC niches, which are functionally supportive of hematopoietic tissue.
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Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.
Guido Carpino,Vincenzo Cardinale,Alessandra Di Giamberardino,Diletta Overi,Samantha Donsante,Tania Colasanti,Gaia Amato,Gianluca Mennini,Matteo Franchitto,Fabrizio Conti,Massimo Rossi,Mara Riminucci,Eugenio Gaudio,Domenico Alvaro,Carmine Mancone +14 more
TL;DR: In this article, the authors investigated which factors released in the intrahepatic cholangiocarcinoma stroma drive the inhibition of angiogenesis and promote lymphangiogenesis.
Journal ArticleDOI
From Stem Cells to Bone-Forming Cells.
Samantha Donsante,Biagio Palmisano,Marta Serafini,Pamela Gehron Robey,Alessandro Corsi,Mara Riminucci +5 more
TL;DR: Osteoblasts are generated by different cohorts of skeletal stem cells that arise from different embryonic specifications, which operate in the pre-natal and/or adult skeleton under the control of multiple regulators.
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Acute myeloid leukemia shapes the bone marrow stromal niche in vivo.
Alice Pievani,Samantha Donsante,Chiara Tomasoni,Alessandro Corsi,Francesco Dazzi,Andrea Biondi,Mara Riminucci,Marta Serafini +7 more
TL;DR: This work evaluated if AML-BMSC have undergone significant changes in their capability to form bone and a BM niche after exposure to patient leukemia in the BM and found that BMSC derived from pediatric AML patients exhibit a reduced mature bone formation and develop an osteoprogenitor-rich niche.