Cristina Remoli

TL;DR: It is shown that muscle pericytes, which are not spontaneously osteochondrogenic as previously claimed, may indeed coincide with an ectopic perivascular subset of committed myogenic cells similar to satellite cells, and the data support the view that different mesoderm derivatives include distinct classes of tissue-specific committed progenitors, possibly of different developmental origin.

TL;DR: It is shown that non-mineralized cartilage pellets formed by hBMSCs ex vivo generate complete ossicles upon heterotopic transplantation in the absence of exogenous scaffolds, showing that an exogenous conductive scaffold is not an absolute requirement for bone formation by transplanted BMSCs.

TL;DR: It is demonstrated that selective silencing of the mutated allele is both feasible and effective in reverting the aberrant cAMP production brought about by the constitutively active Gsα and some of its effects on in vitro differentiation of skeletal progenitors.

TL;DR: Multiple lines of mice are generated that express GsαR201C constitutively and develop an inherited, histopathologically exact replica of human FD, the first model of FD, and are per se compatible with germline transmission and normal embryonic development in mice.

TL;DR: It is concluded that BMT at a very early stage in life markedly reduces signs and symptoms of MPS I before they appear, and the magnitude of improvements correlated with the extent of hematopoietic engraftment.