S
Samantha J. Orenstein
Researcher at Albert Einstein College of Medicine
Publications - 7
Citations - 1505
Samantha J. Orenstein is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Chaperone-mediated autophagy & Autophagy. The author has an hindex of 5, co-authored 7 publications receiving 1355 citations.
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Journal ArticleDOI
Interplay of LRRK2 with chaperone-mediated autophagy
Samantha J. Orenstein,Sheng-Hang Kuo,Inmaculada Tasset,Esperanza Arias,Hiroshi Koga,Irene Fernandez-Carasa,Etty Cortes,Lawrence S. Honig,William T. Dauer,Antonella Consiglio,Antonella Consiglio,Angel Raya,David Sulzer,Ana Maria Cuervo +13 more
TL;DR: This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson’s disease–related protein degraded by this pathway.
Journal ArticleDOI
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification.
Devin M. Wolfe,Ju-Hyun Lee,Ju-Hyun Lee,Asok Kumar,Asok Kumar,Sooyeon Lee,Samantha J. Orenstein,Ralph A. Nixon,Ralph A. Nixon +8 more
TL;DR: The most commonly used pH probes for sensitivity and localisation are evaluated, and LysoSensor yellow/blue‐dextran, among currently used probes, are identified as having the optimal profile of properties for measuring lysosomal pH.
Journal ArticleDOI
Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance
TL;DR: This work has placed particular emphasis on the critical role that changes in the lipid composition of the lysosomal membrane play in the regulation of CMA, as well as the modulatory effect of other novel CMA components.
TECHNICAL SPOTLIGHT Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
Devin M. Wolfe,Ju-Hyun Lee,Asok Kumar,Sooyeon Lee,Samantha J. Orenstein,Ralph A. Nixon,Marion Bessin +6 more
TL;DR: In this article, the authors evaluated the most commonly used pH probes for sensitivity and localisation, and identified LysoSensor yellow/blue-dextran, among currently used probes, as having the optimal profile of properties for measuring lysosomal pH.
Journal ArticleDOI
Chaperone-mediated autophagy at a glance.
Susmita Kaushik,Urmi Bandyopadhyay,Sunandini Sridhar,Roberta Kiffin,Marta Martinez-Vicente,Maria Kon,Samantha J. Orenstein,Esther Wong,Ana Maria Cuervo +8 more
TL;DR: The term autophagy (or self-eating) is an intracellular catabolic pathway that mediates the degradation of a selective subset of cytosolic proteins in lysosomes.