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Etty Cortes
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 62
Citations - 2769
Etty Cortes is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Essential tremor & Purkinje cell. The author has an hindex of 23, co-authored 56 publications receiving 2122 citations. Previous affiliations of Etty Cortes include Columbia University & Columbia University Medical Center.
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Journal ArticleDOI
Interplay of LRRK2 with chaperone-mediated autophagy
Samantha J. Orenstein,Sheng-Hang Kuo,Inmaculada Tasset,Esperanza Arias,Hiroshi Koga,Irene Fernandez-Carasa,Etty Cortes,Lawrence S. Honig,William T. Dauer,Antonella Consiglio,Antonella Consiglio,Angel Raya,David Sulzer,Ana Maria Cuervo +13 more
TL;DR: This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson’s disease–related protein degraded by this pathway.
Journal ArticleDOI
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.
Robin B. Chan,Tiago Gil Oliveira,Etty Cortes,Lawrence S. Honig,Karen Duff,Scott A. Small,Markus R. Wenk,Guanghou Shui,Gilbert Di Paolo +8 more
TL;DR: In this paper, a system-based approach was employed to determine the lipidome of brain tissues affected by Alzheimer disease using liquid chromatography-mass spectrometry to profile extracts from the prefrontal cortex, entorhinal cortex, and cerebellum of late-onset AD patients.
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Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains
Rachel Babij,Michelle Lee,Etty Cortes,Jean Paul G. Vonsattel,Jean Paul G. Vonsattel,Phyllis L. Faust,Elan D. Louis +6 more
TL;DR: A range of changes in the Purkinje cell axonal compartment in essential tremor are document, illustrating an important feature ofPurkinje cells, which is that they are relatively resistant to damage and capable of mobilizing a broad range of axonal responses to injury.
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Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor
Elan D. Louis,Michelle Lee,Rachel Babij,Karen Ma,Etty Cortes,Jean Paul G. Vonsattel,Jean Paul G. Vonsattel,Phyllis L. Faust +7 more
TL;DR: The demonstration of regressive changes in Purkinje cell dendritic architecture and spines in essential tremor relative to control brains provides additional evidence of a pervasive abnormality of Purkinja cell biology in this disease, which affects multiple neuronal cellular compartments.
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Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology
Ming Kai Pan,Yong Shi Li,Shi Bing Wong,Chun Lun Ni,Yi Mei Wang,Wen Chuan Liu,Liang Yin Lu,Jye Chang Lee,Etty Cortes,Jean Paul G. Vonsattel,Qian Sun,Qian Sun,Elan D. Louis,Phyllis L. Faust,Sheng-Han Kuo +14 more
TL;DR: A pathophysiologic contribution to tremor at molecular (GluRδ2), structural (CF-to-PC synapses), physiological (cerebellar oscillations), physiological and behavioral levels (kinetic tremor) that might have clinical applications for treating ET are identified.