D
Devin M. Wolfe
Researcher at Nathan Kline Institute for Psychiatric Research
Publications - 11
Citations - 1993
Devin M. Wolfe is an academic researcher from Nathan Kline Institute for Psychiatric Research. The author has contributed to research in topics: Autophagy & Lysosome. The author has an hindex of 8, co-authored 11 publications receiving 1770 citations. Previous affiliations of Devin M. Wolfe include University of Rochester.
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Journal ArticleDOI
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee,Ju-Hyun Lee,W. Haung Yu,W. Haung Yu,Asok Kumar,Asok Kumar,Sooyeon Lee,Sooyeon Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Corrinne M. Peterhoff,Devin M. Wolfe,Marta Martinez-Vicente,Ashish C. Massey,Guy Sovak,Yasuo Uchiyama,David Westaway,Ana Maria Cuervo,Ralph A. Nixon,Ralph A. Nixon +19 more
TL;DR: It is shown that macroautophagy requires the Alzheimer's disease-related protein presenilin-1 (PS1) for v-ATPase targeting to lysosomes, lysOSome acidification, and proteolysis during autophagy, which represents a basis for pathogenic protein accumulations and neuronal cell death in AD.
Journal ArticleDOI
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification.
Devin M. Wolfe,Ju-Hyun Lee,Ju-Hyun Lee,Asok Kumar,Asok Kumar,Sooyeon Lee,Samantha J. Orenstein,Ralph A. Nixon,Ralph A. Nixon +8 more
TL;DR: The most commonly used pH probes for sensitivity and localisation are evaluated, and LysoSensor yellow/blue‐dextran, among currently used probes, are identified as having the optimal profile of properties for measuring lysosomal pH.
Journal ArticleDOI
Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
Ju-Hyun Lee,Mary Kate McBrayer,Devin M. Wolfe,Luke J. Haslett,Asok Kumar,Yutaka Sato,Pearl P.Y. Lie,Panaiyur S. Mohan,Panaiyur S. Mohan,Erin E. Coffey,Uday B. Kompella,Claire H. Mitchell,Emyr Lloyd-Evans,Ralph A. Nixon,Ralph A. Nixon +14 more
TL;DR: The results indicate that vATPase deficiency in PS1 loss-of-function states causes lysosomal/autophagy deficits and contributes to abnormal cellular Ca(2+) homeostasis, thus linking two AD-related pathogenic processes through a common molecular mechanism.
TECHNICAL SPOTLIGHT Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
Devin M. Wolfe,Ju-Hyun Lee,Asok Kumar,Sooyeon Lee,Samantha J. Orenstein,Ralph A. Nixon,Marion Bessin +6 more
TL;DR: In this article, the authors evaluated the most commonly used pH probes for sensitivity and localisation, and identified LysoSensor yellow/blue-dextran, among currently used probes, as having the optimal profile of properties for measuring lysosomal pH.
Journal ArticleDOI
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2.
TL;DR: The Saccharomyces cerevisiae gene YPK9p encodes a putative integral membrane protein which is 58% similar and 38% identical in amino acid sequence to the human lysosomal P(5B) ATPase ATP13A2 as discussed by the authors.