Journal ArticleDOI
Quinoline derivatives bearing pyrazole moiety: Synthesis and biological evaluation as possible antibacterial and antifungal agents
Mohamed F. El Shehry,Mostafa M. Ghorab,Samir Y. Abbas,Eman A. Fayed,Said A. Shedid,Yousry A. Ammar +5 more
TLDR
The synthesized quinoline derivatives bearing pyrazole moiety are interesting scaffolds for the development of novel antibacterial and antifungal agents according to the tested strains of bacteria and fungi.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2018-01-01. It has received 133 citations till now. The article focuses on the topics: Pyrazole & Quinoline.read more
Citations
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Journal ArticleDOI
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Khalid Karrouchi,Smaail Radi,Youssef Ramli,Jamal Taoufik,Yahia N. Mabkhot,Faiz A. Al-aizari,M'hammed Ansar +6 more
TL;DR: The different synthesis methods and the pharmacological properties of pyrazole derivatives developed by many scientists around the globe are highlighted.
Journal ArticleDOI
A comprehensive review on the biological interest of quinoline and its derivatives.
TL;DR: A review of quinoline-based marketed drugs can be found in this paper, where the authors provide information about the biological activities of these drugs, such as antibacterial, antifungal, antimycobacterial, antiviral, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.
Journal ArticleDOI
Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review
Abdanne Weyesa,Endale Mulugeta +1 more
TL;DR: Various selected quinolines and derivatives with potential biological and pharmaceutical activities will be presented and synthesis protocols used up to now for the construction of the principal quinoline scaffold are highlighted.
Journal ArticleDOI
Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies.
Sally I. Eissa,Amel M. Farrag,Samir Y. Abbas,Mohamed F. El Shehry,Ahmed Ragab,Eman A. Fayed,Yousry A. Ammar +6 more
TL;DR: One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold, so quinolines bearing a thiazole moiety can be suggested as interesting scaffolds for the development both of the novel antibacterial and antifungal agents.
Journal ArticleDOI
Design, synthesis, and antifungal evaluation of novel quinoline derivatives inspired from natural quinine alkaloids.
Guan-Zhou Yang,Jia-Kai Zhu,Xiao-Dan Yin,Yin-Fang Yan,Yu-Ling Wang,Xiao-Fei Shang,Ying-Qian Liu,Zhong-Min Zhao,Peng Jingwen,Hua Liu +9 more
TL;DR: Results indicate that compounds 3f-4 and3f-28 are a novel potential fungicidal candidate against S. sclerotiorum derived from natural products.
References
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Journal ArticleDOI
Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.
Annamaria Lilienkampf,Jialin Mao,Baojie Wan,Yuehong Wang,Scott G. Franzblau,Alan P. Kozikowski +5 more
TL;DR: The results suggest that quinoline-isoxazole-based anti-TB compounds are promising leads for new TB drug development.
Journal ArticleDOI
Treatment of acute vivax malaria with tafenoquine.
Peter Nasveld,Scott Kitchener +1 more
TL;DR: The rapid parasite clearances observed, coupled with a good clinical response and lack of recrudescence or relapse, indicate that further investigation of tafenoquine in the treatment of vivax malaria is warranted.
Journal ArticleDOI
Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents
K.D. Thomas,Airody Vasudeva Adhikari,Sandeep Telkar,Imran H. Chowdhury,Riaz Mahmood,Nishith Kumar Pal,Guru Tayur N Row,E. Sumesh +7 more
TL;DR: Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions and displayed promising antimicrobial activity including antimycobacterial activity.
Journal ArticleDOI
Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach
Amol H. Kategaonkar,Pravin V. Shinde,Atul H. Kategaonkar,Sharad K. Pasale,Bapurao B. Shingate,Murlidhar S. Shingare +5 more
TL;DR: Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2, 3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) has been achieved in very high yield.