S
Sander W. Tas
Researcher at University of Amsterdam
Publications - 139
Citations - 3211
Sander W. Tas is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Rheumatoid arthritis. The author has an hindex of 25, co-authored 101 publications receiving 2154 citations. Previous affiliations of Sander W. Tas include Catholic University of Leuven & Université catholique de Louvain.
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Journal ArticleDOI
Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
Marlijn van der Poel,Thomas Ulas,Mark R. Mizee,Cheng-Chih Hsiao,Suzanne S. M. Miedema,Adelia,Karianne G. Schuurman,Boy Helder,Sander W. Tas,Joachim L. Schultze,Joachim L. Schultze,Jörg Hamann,Jörg Hamann,Inge Huitinga +13 more
TL;DR: Significant intrinsic differences in the human microglial transcriptome between grey and white matter regions are demonstrated, isolated from MS and non-neurological control donors, and show early microglia changes related to MS pathology.
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Occupational Hazards for the Male Reproductive System
TL;DR: The objective of this work is to summarize the main epidemiological and experimental findings pertaining to agents (physical and chemical) encountered in the occupational environment that might affect the male reproductive system and/or related pregnancy outcomes (spontaneous abortion, stillbirth, low birth weight, and birth defects and childhood malignancy in offspring).
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Noncanonical NF-κB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
Sander W. Tas,Margriet J. Vervoordeldonk,Najat Hajji,Joost H. N. Schuitemaker,Koen van der Sluijs,Michael J. May,Sankar Ghosh,Martien L. Kapsenberg,Paul P. Tak,Esther C. de Jong +9 more
TL;DR: Selective activation of the noncanonical NF-kappaB pathway results in noninflammatory DCs that suppress T-cell activation and promote the development of T cells with regulatory properties, which reveal an important role of thenoncanonicalNF-kappB pathway in the regulation of immunity.
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Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles
M Cristina Lebre,Sarah L. Jongbloed,Sander W. Tas,Tom J. M. Smeets,Iain B. McInnes,Paul P. Tak +5 more
TL;DR: The data characterize the phenotypes of mDCs and pDCs in inflammatory synovitis and define for the first time the cytokine expression profile of these DC subsets.
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Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis : the PRAIRI study
Danielle M. Gerlag,M Safy,KI Maijer,Man Wai Tang,Sander W. Tas,M. Starmans-Kool,Astrid van Tubergen,Matthijs Janssen,Maria J. H. de Hair,Monika Hansson,Niek de Vries,Aeilko H. Zwinderman,Paul P. Tak +12 more
TL;DR: A single infusion of 1000 mg rituximab significantly delays the development of arthritis in subjects at risk of developing RA, providing evidence for the pathogenetic role of B cells in the earliest, prearthritis stage of autoantibody positive RA.