S
Sándor Lovas
Researcher at Creighton University
Publications - 117
Citations - 3092
Sándor Lovas is an academic researcher from Creighton University. The author has contributed to research in topics: Receptor & Binding site. The author has an hindex of 28, co-authored 114 publications receiving 2894 citations. Previous affiliations of Sándor Lovas include University of Düsseldorf & Wistar Institute.
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Journal ArticleDOI
The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding.
TL;DR: The data suggest that drosocin and pyrrhocoricin binding prevents the frequent opening and closing of the multihelical lid over the peptide-binding pocket of DnaK, permanently closes the cavity, and inhibits chaperone-assisted protein folding.
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Interaction between Heat Shock Proteins and Antimicrobial Peptides
Laszlo Otvos,Rogers Me,Consolvo Pj,Barry A. Condie,Sándor Lovas,Philippe Bulet,Magdalena Blaszczyk-Thurin +6 more
TL;DR: All three antibacterial peptides strongly interacted with two bacterial lipopolysaccharide preparations in solution, indicating that the initial step of the bacterial killing cascade proceeds through LPS-mediated cell entry.
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Primary structure and biological activity of a third gonadotropin-releasing hormone from lamprey brain.
TL;DR: It is proposed based on the biological activity of lampreys GnRH-III in these studies and the occurrence of this peptide during metamorphosis in lampreys, that both lamprey Gn RH-I and -III are neurohormones involved in reproduction in lamprey.
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Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
Laszlo Otvos,Eva Haspinger,Eva Haspinger,Francesca La Russa,Francesca La Russa,Federica Maspero,Federica Maspero,Patrizia Graziano,Patrizia Graziano,Ilona Kovalszky,Sándor Lovas,Kaushik Nama,Ralf Hoffmann,Daniel Knappe,Marco Cassone,John D. Wade,Eva Surmacz +16 more
TL;DR: Its biological activity, superior stability in biological fluids as well as acceptable toxicity profile indicate that the peptidomimetic represents a true lead compound for pharmaceutical development to replace low adiponectin levels in cancer and other malignancies.
Journal ArticleDOI
Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin.
Goran Kragol,Ralf Hoffmann,Michael A. Chattergoon,Sándor Lovas,Mare Cudic,Philippe Bulet,Barry A. Condie,K. Johan Rosengren,Luis J. Montaner,Laszlo Otvos +9 more
TL;DR: Findings highlighted pyrrhocoricin's suitability for combating intracellular pathogens and raised the possibility that the proline-rich antibacterial peptides can deliver drug leads into mammalian cells.