Ilona Kovalszky

TL;DR: Its biological activity, superior stability in biological fluids as well as acceptable toxicity profile indicate that the peptidomimetic represents a true lead compound for pharmaceutical development to replace low adiponectin levels in cancer and other malignancies.

TL;DR: Robust genetic evidence for a direct role of endogenous decorin in preventing and retarding hepatic fibrosis is provided and boosting the endogenous production of decorin or systemic delivery of recombinant decorin could represent an additional therapeutic modality against liver fibrosis.

TL;DR: There are distinct maternal and placental disease pathways, and their interaction influences the clinical presentation of preeclampsia, and the description of these novel pathways in the “molecular phase” of preeClampsia and the identification of their hub molecules may enable timely molecular characterization of patients with distinct phenotypes.

TL;DR: The results indicate that leptin receptor antagonists could become attractive options for triple-negative breast cancer treatment, especially in the obese patient population.

TL;DR: High-throughput transcriptional and tissue microarray expression profiling revealed that placental transcriptomes of early-onset preeclampsia and HELLP syndrome largely overlap, underlying a potential common cause and pathophysiologic processes in these syndromes.