Sandra Diaz

TL;DR: It is found that Neu5Gc is rare in poultry and fish, common in milk products, and enriched in red meats, and normal humans have variable amounts of circulating IgA, IgM, and IgG antibodies against Neu 5Gc, with the highest levels comparable to those of the previously known anti-α-galactose xenoreactive antibodies.

TL;DR: In this paper, the authors reported cloning of human and chimpanzee hydroxylase cDNAs, which is similar to the murine homologue, but the human cDNA contains a 92-bp deletion resulting in a frameshift mutation.

TL;DR: It is shown that free Neu5Gc uptake also occurs in other human and mammalian cells, and this is the first example of delivery to the cytosol of an extracellular small molecule that cannot cross the plasma membrane, utilizing fluid pinocytosis and a specific lysosomal transporter.

TL;DR: It is shown that the Neu5Gc content of cultured human and nonhuman cell lines and their secreted glycoproteins can be reduced by adding a human sialic acid to the culture medium, which may be relevant to improving the half-life, efficacy and immunogenicity of glycoprotein therapeutics.

TL;DR: The studies indicate that the CMAH gene was inactivated shortly before the time when brain expansion began in humankind's ancestry, ≈2.1–2.2 mya.