Sandra Hoefgen

TL;DR: The APP-based signal transduction, cell–cell- and/or cell–ECM interaction should depend on dimerization induced by heparin, as well as on pH, arguing that APP could fulfill different functions depending on its (sub)cellular localization.

TL;DR: A sophisticated, yet easy-to-assemble vector system to heterologously express multiple genes under the control of a single promoter was successfully applied to produce the psychotropic mushroom alkaloid psilocybin in high yields by heterologous expression of the entire biosynthetic gene cluster in the mould Aspergillus nidulans.

TL;DR: It is demonstrated that MpkB is important for conidiation and that its deletion induces a copious increase of dihydroxynaphthalene (DHN)-melanin production, which can determine the failure of effective treatment of invasive mycoses using antifungal drugs.

TL;DR: Current understanding of the structure-function-relationship of the multi-domain protein APP, which consists of the two folded E1 and E2 segments that are connected to one another and to the single transmembrane helix by flexible segments, is summarized.

TL;DR: The plasticity of the CBC: HapX:DNA interaction permits fine tuning of CBC:HapX binding specificities that could support adaptation of pathogens to their host niches.