Sandra M. Holley

TL;DR: It is shown that reduction of cortical mHTT expression in BACHD mice partially improves motor and psychiatric-like behavioral deficits but does not improve neurodegeneration, whereas reduction of mHTt expression in both neuronal populations consistently ameliorates all behavioral deficits and selective brain atrophy in this HD model.

TL;DR: It is shown that basolateral amygdala to orbitofrontal cortex projections are required for expectations of specific available rewards to influence reward seeking and decision making, and these projections facilitate adaptive behavior by enabling the orbitof prefrontal cortex to use environmental stimuli to generate expectations of potential future rewarding events.

TL;DR: Findings provide strong evidence that both feedforward and to a lesser extent feedback inhibition to MSNs in HD can potentially be sources for the increased GABA synaptic activity of indirect pathway MSNs.

TL;DR: This work unexpectedly finds that both suppressing and over-activating PV cells attenuates spontaneous MSN activity, and provides a possible mechanism by which PV interneurons modulate striatal output and selectively enhance performance early in learning.

TL;DR: It is demonstrated that dorsal LCI have a unique requirement for torsinA function during striatal maturation, and abnormalities of these cells to dystonic-like movements in an overtly symptomatic animal model are linked.