S
Sandra M. Kolkman-Uljee
Researcher at Leiden University Medical Center
Publications - 12
Citations - 705
Sandra M. Kolkman-Uljee is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Serous fluid & Cancer. The author has an hindex of 10, co-authored 12 publications receiving 683 citations. Previous affiliations of Sandra M. Kolkman-Uljee include Leiden University.
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Journal ArticleDOI
In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low‐grade serous tumours
Nathalie L.G. Sieben,Patricia Macropoulos,Guido M.J.M. Roemen,Sandra M. Kolkman-Uljee,Gert Jan Fleuren,Rifat Houmadi,Tim C. Diss,Bretta Warren,Mudher Al Adnani,Anton F.P.M. de Goeij,Thomas Krausz,Adrienne M. Flanagan +11 more
TL;DR: The finding that at least 60% of serous borderline tumours harbour mutations in two members of the ERK‐MAP‐kinase pathway compared with 12% of high‐grade serous carcinomas (BRAF 0%, KRAS 12%) indicates that the majority of serious borderline tumoured tumours do not progress to serious carcinomas.
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Differential Gene Expression in Ovarian Tumors Reveals Dusp 4 and Serpina 5 As Key Regulators for Benign Behavior of Serous Borderline Tumors
Nathalie L.G. Sieben,Jan Oosting,Adrienne M. Flanagan,Jaime Prat,Guido M.J.M. Roemen,Sandra M. Kolkman-Uljee,Ronald van Eijk,Cees J. Cornelisse,Gert Jan Fleuren,Manon van Engeland +9 more
TL;DR: It is proposed that the putative tumor suppressor genes Dusp 4 and Serpina 5 provide a major clue to the indolent behavior of SBTs.
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Prevalence of single and multiple HPV types in cervical carcinomas in Jakarta, Indonesia
Maaike C Schellekens,Anneke Dijkman,Mohammad Farid Aziz,Budiningsih Siregar,Santoso Cornain,Sandra M. Kolkman-Uljee,Lex A.W. Peters,Gert Jan Fleuren +7 more
TL;DR: The high amount of multiple HPV infections found in adenosquamous carcinomas may prompt further research on the pathogenesis of this type of cervical tumours.
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Human papillomavirus type 16 E6, E7, and L1 variants in cervical cancer in Indonesia, Suriname, and the Netherlands
Marjon A. de Boer,Lex A.W. Peters,Mohammed Farid Aziz,Budiningsih Siregar,Santoso Cornain,M. Albert Vrede,Ekaterina S. Jordanova,Sandra M. Kolkman-Uljee,Gert Jan Fleuren +8 more
TL;DR: The majority of the HPV 16-positive cervical cancers in Indonesia are caused by a specific intratypic variant that was rarely found before in other countries.
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A Novel Strategy for Human Papillomavirus Detection and Genotyping with SybrGreen and Molecular Beacon Polymerase Chain Reaction
Karoly Szuhai,Emily Sandhaus,Sandra M. Kolkman-Uljee,Marc Lemaitre,Jean-Christophe Truffert,Roeland W. Dirks,Hans J. Tanke,Gert Jan Fleuren,Ed Schuuring,Anton K. Raap +9 more
TL;DR: It is concluded that the HPV SybrGreen-PCR in combination with the HPV molecular beacon PCR provides a robust, sensitive, and quantitative general HPV detection and genotyping methodology.