Sandra Tenreiro

TL;DR: The YEAst Search for Transcriptional Regulators And Consensus Tracking (YEASTRACT; ) database is a repository of 12 346 regulatory associations between transcription factors and target genes, based on experimental evidence which was spread throughout 861 bibliographic references.

TL;DR: Recent findings in the field are covered and how targeting phosphorylation events might be used for therapeutic intervention in these devastating diseases of the nervous system are discussed.

TL;DR: The Yeast search for transcriptional regulators and consensus tracking (YEASTRACT) information system was developed to support the analysis of transcription regulatory associations in Saccharomyces cerevisiae and includes DISCOVERER, a set of computational tools that can be used to identify complex motifs over-represented in the promoter regions of co-regulated genes.

TL;DR: Data suggest that direct interactions between DJ-1 and aSyn constitute the basis for a neuroprotective mechanism and that familial mutations inDJ-1 may contribute to PD by disrupting these interactions.

TL;DR: The finding that the phosphorylation state of aSyn on S129 can alter the ability of cells to clear aSyn inclusions provides important insight into the role that this posttranslational modification may have in the pathogenesis of PD and other synucleinopathies, opening novel avenues for investigating the molecular basis of these disorders and for the development of therapeutic strategies.