M
Mariaelena Repici
Researcher at University of Leicester
Publications - 14
Citations - 1158
Mariaelena Repici is an academic researcher from University of Leicester. The author has contributed to research in topics: Neurodegeneration & Biology. The author has an hindex of 10, co-authored 11 publications receiving 1034 citations. Previous affiliations of Mariaelena Repici include Aston University.
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Journal ArticleDOI
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Tiziana Borsello,Peter G.H. Clarke,Lorenz Hirt,Alessandro Vercelli,Mariaelena Repici,Daniel F. Schorderet,Julien Bogousslavsky,Christophe Bonny +7 more
TL;DR: A cell-penetrating, protease-resistant peptide that blocks the access of JNK to many of its targets is evaluated and is found to be a promising neuroprotective agent for stroke.
Journal ArticleDOI
DJ-1 interactions with α -synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease
L Zondler,Leonor Miller-Fleming,Mariaelena Repici,Susana Gonçalves,Sandra Tenreiro,Rita Rosado-Ramos,Cristine Betzer,K.R. Straatman,Poul Henning Jensen,Flaviano Giorgini,Tiago F. Outeiro +10 more
TL;DR: Data suggest that direct interactions between DJ-1 and aSyn constitute the basis for a neuroprotective mechanism and that familial mutations inDJ-1 may contribute to PD by disrupting these interactions.
Journal ArticleDOI
DJ-1 in Parkinson's Disease: Clinical Insights and Therapeutic Perspectives.
TL;DR: An overview of the clinical research to date on DJ-1 and the current state of knowledge regardingDJ-1 characterization in the human brain is provided and the relevance of DJs-1 as a PD biomarker is discussed.
Journal ArticleDOI
Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease
Alexandra Auffret,Vanessa Gautheron,Mariaelena Repici,Rudolf Kraftsik,Howard T.J. Mount,Jean Mariani,Catherine Rovira +6 more
TL;DR: The view that the PS1 overexpression promotes synaptic dysfunction in an Aβ-independent manner is supported and the crucial role of PS1 during both normal and pathological aging is underline.
Journal ArticleDOI
Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders
Sophie Erhardt,Ana Pocivavsek,Mariaelena Repici,Xi-Cong Liu,Sophie Imbeault,Daniel C. Maddison,Marian A. R. Thomas,Joshua L. Smalley,Markus K. Larsson,Paul J. Muchowski,Flaviano Giorgini,Robert Schwarcz +11 more
TL;DR: Results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders.