S
Sandra Won
Researcher at University of Virginia
Publications - 4
Citations - 464
Sandra Won is an academic researcher from University of Virginia. The author has contributed to research in topics: Neuregulin & ErbB. The author has an hindex of 4, co-authored 4 publications receiving 444 citations.
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Journal ArticleDOI
Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
Yang Zhong Huang,Yang Zhong Huang,Yang Zhong Huang,Sandra Won,Declan W. Ali,Qiang Wang,Qiang Wang,Qiang Wang,Michael Tanowitz,Quan S. Du,Kenneth A Pelkey,Da-Jun Yang,Wen Cheng Xiong,Michael W. Salter,Lin Mei,Lin Mei +15 more
TL;DR: NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission, suggesting that NRG signaling may be synaptic and regulated by PSD-95.
Journal ArticleDOI
Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function
TL;DR: It is proposed that PDZ domain‐containing proteins play a role in anchoring ErbB proteins at the neuromuscular junction, and/or mediating downstream signaling pathways that could be important for the maintenance and function of the synapse.
Journal ArticleDOI
Neuregulin‐Increased Expression of Acetylcholine Receptorε‐Subunit Gene Requires ErbB Interaction with Shc
Sandra Won,Jutong Si,Marcie Colledge,Marcie Colledge,Kodimangalam S. Ravichandran,Stanley C. Froehner,Lin Mei +6 more
TL;DR: Investigation of the neuregulin transduction mechanism that leads to ERK activation after ErbB receptor tyrosine phosphorylation indicates that the interaction ofErbB receptors with Grb2 alone is insufficient for neurgulin‐activated transcription, but that Erb B receptor signaling via Shc is necessary and important.
Journal ArticleDOI
Regulation by ARIA/neuregullin of acetylcholine receptor gene transcription at the neuromuscular junction
TL;DR: Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane.