Q
Qiang Wang
Researcher at Johns Hopkins University School of Medicine
Publications - 17
Citations - 2001
Qiang Wang is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Agrin & Neuromuscular junction. The author has an hindex of 15, co-authored 17 publications receiving 1883 citations. Previous affiliations of Qiang Wang include Chinese Academy of Sciences & University of Alabama at Birmingham.
Papers
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Journal ArticleDOI
LRP4 serves as a coreceptor of agrin.
TL;DR: Observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies.
Journal ArticleDOI
Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
Yang Zhong Huang,Yang Zhong Huang,Yang Zhong Huang,Sandra Won,Declan W. Ali,Qiang Wang,Qiang Wang,Qiang Wang,Michael Tanowitz,Quan S. Du,Kenneth A Pelkey,Da-Jun Yang,Wen Cheng Xiong,Michael W. Salter,Lin Mei,Lin Mei +15 more
TL;DR: NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission, suggesting that NRG signaling may be synaptic and regulated by PSD-95.
Journal ArticleDOI
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1
Zhen G Luo,Qiang Wang,Qiang Wang,Jian Z Zhou,Jianbo Wang,Zhijun Luo,Mingyao Liu,Xi He,Anthony Wynshaw-Boris,Wen Cheng Xiong,Bai Lu,Lin Mei +11 more
TL;DR: It is reported here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity, and this interaction inhibits Agrin- and neuron-induced AChR clustering and reveals a novel function of Dvl in synapse development.
Journal ArticleDOI
Focal adhesion kinase in netrin-1 signaling
Xiu Rong Ren,Guo Li Ming,Yi Xie,Yan Hong,Dong Mei Sun,Zhong Qiu Zhao,Zhu Feng,Zhu Feng,Qiang Wang,Qiang Wang,Sangwoo Shim,Zhou-Feng Chen,Hongjun Song,Lin Mei,Lin Mei,Wen Cheng Xiong,Wen Cheng Xiong +16 more
TL;DR: It is reported that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion kinase (FAK), a kinase implicated in regulating cell adhesion and migration, and this results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin -1 function.
Journal ArticleDOI
Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin
Qiang Wang,Yi Xie,Quansheng Du,Quansheng Du,Xiaojun Wu,Xu Feng,Lin Mei,Jay M. McDonald,Jay M. McDonald,Wen Cheng Xiong +9 more
TL;DR: Evidence is provided that PYK2 directly interacts with gelsolin, an actin binding, severing, and capping protein essential for osteoclastic actin cytoskeletal organization, and a novel PyK2–gelsolin pathway in regulating act in cytoskeleton organization in multiple cells, including osteoclasts is revealed.