Sandro Loche

TL;DR: To investigate whether the severity of GHD was correlated with the degree of bone mass and turnover impairment, BMD at the lumbar spine and femoral neck was evaluated and circulating IGF-I, IGF-binding protein-3, and osteocalcin levels, and urinary cross-linked N-telopeptides of type I collagen (Ntx) levels were evaluated.

TL;DR: Plasma somatomedin‐C (SM‐C) levels were significantly higher in obese than control children, and were negatively correlated with the peak plasma GH levels, implying that it may be due to the feedback inhibition operated by the elevated plasma levels of SM‐C.

TL;DR: None of these tests can be considered completely reliable for establishing or excluding the presence of secondary or tertiary adrenal insufficiency and clinical judgment remains one of the most important issues for deciding which patients need assessment or re-assessment of adrenal function.

TL;DR: The results indicate that the LH response to NLX occurs only at the most advanced stages of pubertal maturation when normal or precocious and is absent in early puberty or in children with Pubertal disturbances, and suggest that opioid regulation of LH secretion in humans changes during puberty, reaching an adult-like functional state with maturation of the hypothalamus-pituitary-gonadal axis.

TL;DR: GAL is a potent GH secretagogue in the infant rat and the action of GAL is not exerted directly on GHRF- or somatostatin-secreting structures, but requires the intervention of catecholaminergic neurons.