Jan Cerny

TL;DR: It is proposed that tubular endosomes extend intracellularly and polarize towards the interacting T cell, but only when antigen-laden dendritic cells encounter T cells of the appropriate specificity, and serves to facilitate the ensuing T-cell response.

TL;DR: In this paper, the authors investigated if sustained siRNA-mediated silencing of human immunodeficiency virus type 1 (HIV-1) is possible in terminally differentiated macrophages, which constitute an important reservoir of HIV in vivo.

TL;DR: It is suggested that lysosomes are dispensable for resealing after wounding because cells heal normally in the presence of vacuolin‐1, the most potent compound.

TL;DR: A large-scale RNA interference screen reveals a new mechanism of imatinib resistance in chronic myeloid leukemia that can be therapeutically targeted and demonstrates that a U.S. Food and Drug Administration–approved drug can overcome this resistance and kill leukemia stem cells without harming the nonmalignant precursors that give rise to normal blood cells.

TL;DR: A Toll-like receptor-dependent signal is required to allow Ag-loaded dendritic cells to respond to T cell contact by formation of extended endosomal compartments, which does not result in massive translocation of class II MHC molecules to the cell surface.