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Ronald G. Collman

Researcher at University of Pennsylvania

Publications -  233
Citations -  24599

Ronald G. Collman is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Virus & Microbiome. The author has an hindex of 70, co-authored 212 publications receiving 21785 citations. Previous affiliations of Ronald G. Collman include Beth Israel Deaconess Medical Center & Scripps Research Institute.

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

TL;DR: It is shown that a mutant allele of CCR-5 is present at a high frequency in caucasian populations, but is absent in black populations from Western and Central Africa and Japanese populations, and a 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains.
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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.

TL;DR: The results suggest that the T- Tropic viruses characteristic of disease progression may evolve from purely M-tropic viruses prevalent early in virus infection through changes in the env protein that enable the virus to use multiple entry cofactors.
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Bayesian community-wide culture-independent microbial source tracking

TL;DR: SourceTracker, a Bayesian approach to estimate the proportion of contaminants in a given community that come from possible source environments, is presented, and microbial surveys from neonatal intensive care units, offices and molecular biology laboratories are applied.