R
Ronald G. Collman
Researcher at University of Pennsylvania
Publications - 233
Citations - 24599
Ronald G. Collman is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Virus & Microbiome. The author has an hindex of 70, co-authored 212 publications receiving 21785 citations. Previous affiliations of Ronald G. Collman include Beth Israel Deaconess Medical Center & Scripps Research Institute.
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Journal ArticleDOI
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
Michel Samson,Frédérick Libert,Benjamin J. Doranz,Joseph Rucker,Corinne Liesnard,Claire-Michèle Farber,Sentob Saragosti,Claudine Lapoumeroulie,Jacqueline Cognaux,Christine Forceille,Gaëtan Muyldermans,Chris Verhofstede,Guy Burtonboy,Michel Georges,Tsuneo Imai,Shalini Rana,Yanji Yi,Robert J. Smyth,Ronald G. Collman,Robert W. Doms,Gilbert Vassart,Marc Parmentier +21 more
TL;DR: It is shown that a mutant allele of CCR-5 is present at a high frequency in caucasian populations, but is absent in black populations from Western and Central Africa and Japanese populations, and a 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains.
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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
Benjamin J. Doranz,Joseph Rucker,Yanjie Yi,Robert J. Smyth,Michel Samson,Stephen C. Peiper,Marc Parmentier,Ronald G. Collman,Robert W. Doms +8 more
TL;DR: The results suggest that the T- Tropic viruses characteristic of disease progression may evolve from purely M-tropic viruses prevalent early in virus infection through changes in the env protein that enable the virus to use multiple entry cofactors.
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more
TL;DR: A critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus is demonstrated.
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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
Pablo Tebas,David Stein,Winson Tang,Ian Frank,Shelley Wang,Gary Lee,S. Kaye Spratt,Richard T. Surosky,Martin Giedlin,Geoff Nichol,Michael C. Holmes,Philip D. Gregory,Dale G. Ando,Michael Kalos,Ronald G. Collman,Gwendolyn Binder-Scholl,Gabriela Plesa,Wei-Ting Hwang,Bruce L. Levine,Carl H. June +19 more
TL;DR: CCR5-modified autologous CD4 T-cell infusions are safe within the limits of this study, and HIV RNA became undetectable in one of four patients who could be evaluated.
Journal ArticleDOI
Bayesian community-wide culture-independent microbial source tracking
Dan Knights,Justin Kuczynski,Emily S. Charlson,Jesse R. Zaneveld,Michael C. Mozer,Ronald G. Collman,Frederic D. Bushman,Rob Knight,Rob Knight,Scott T. Kelley +9 more
TL;DR: SourceTracker, a Bayesian approach to estimate the proportion of contaminants in a given community that come from possible source environments, is presented, and microbial surveys from neonatal intensive care units, offices and molecular biology laboratories are applied.