Sang-Woon Choi

TL;DR: The results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status, and is known to be solely represented in those individuals.

TL;DR: This review presents those mechanisms which are the most likely candidates to explain folate's effects and it proposes an integrated scheme to explain how these mechanisms might interact.

TL;DR: Current knowledge in nutritional epigenetics is limited, and further studies are needed to expand the available resources and better understand the use of nutrients or bioactive food components for maintaining the authors' health and preventing diseases through modifiable epigenetic mechanisms.

TL;DR: The data suggest that Tet1 loss leading to a partial reduction in 5hmC levels does not affect pluripotency in ESCs and is compatible with embryonic and postnatal development.

TL;DR: DNA methylation was directly and significantly related to RBC folate concentrations in persons with the T/T genotype, but not in those with wild-type MTHFR, consistent with prior observations, which suggest that the T or T genotype is associated with impaired MTH FR activity in vivo and that the cellular impact of this impairment is determined, in part, by folate status.