M
Meelad M. Dawlaty
Researcher at Albert Einstein College of Medicine
Publications - 48
Citations - 9354
Meelad M. Dawlaty is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Embryonic stem cell & DNA methylation. The author has an hindex of 28, co-authored 41 publications receiving 8020 citations. Previous affiliations of Meelad M. Dawlaty include Massachusetts Institute of Technology & Mayo Clinic.
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Journal ArticleDOI
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.
Haoyi Wang,Hui Yang,Chikdu S. Shivalila,Meelad M. Dawlaty,Albert W. Cheng,Feng Zhang,Feng Zhang,Rudolf Jaenisch +7 more
TL;DR: The CRISPR/Cas system allows the one-step generation of animals carrying mutations in multiple genes, an approach that will greatly accelerate the in vivo study of functionally redundant genes and of epistatic gene interactions.
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Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency
Thorold W. Theunissen,Benjamin E. Powell,Haoyi Wang,Maya Mitalipova,Dina A. Faddah,Jessica Reddy,Zi Peng Fan,Dorothea Maetzel,Kibibi Ganz,Linyu Shi,Tenzin Lungjangwa,Sumeth Imsoonthornruksa,Yonatan Stelzer,Sudharshan Rangarajan,Ana C. D’Alessio,Jianming Zhang,Qing Gao,Meelad M. Dawlaty,Richard A. Young,Nathanael S. Gray,Rudolf Jaenisch +20 more
TL;DR: In this paper, the authors identify small molecules that support self-renewal of naive human ESCs based on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state pluripotency.
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency
Thorold W. Theunissen,Benjamin E. Powell,Haoyi Wang,Maya Mitalipova,Dina A. Faddah,Jessica Reddy,Zi Peng Fan,Dorothea Maetzel,Kibibi Ganz,Linyu Shi,Tenzin Lungjangwa,Sumeth Imsoonthornruksa,Yonatan Stelzer,Sudharshan Rangarajan,Ana C. D’Alessio,Jianming Zhang,Qing Gao,Meelad M. Dawlaty,Richard A. Young,Nathanael S. Gray,Rudolf Jaenisch +20 more
TL;DR: Comparison with previously reported naive human ESCs indicates that the conditions captured in this study capture a distinct pluripotent state in humans that closely resembles that of mouse ESCs.
Journal ArticleDOI
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.
Meelad M. Dawlaty,Kibibi Ganz,Benjamin E. Powell,Yueh-Chiang Hu,Styliani Markoulaki,Albert W. Cheng,Qing Gao,Jongpil Kim,Sang-Woon Choi,David C. Page,David C. Page,Rudolf Jaenisch +11 more
TL;DR: The data suggest that Tet1 loss leading to a partial reduction in 5hmC levels does not affect pluripotency in ESCs and is compatible with embryonic and postnatal development.
Journal ArticleDOI
Reprogramming of human peripheral blood cells to induced pluripotent stem cells.
Judith Staerk,Meelad M. Dawlaty,Qing Gao,Dorothea Maetzel,Jacob H. Hanna,Cesar Sommer,Gustavo Mostoslavsky,Rudolf Jaenisch +7 more
TL;DR: A polycistronic vector encoding Oct4, Klf4, Sox2 and c-Myc is used to generate iPS cells from from frozen peripheral blood of several donors and these cells were derived from mature T cells as well as myeloid donor cells.