S
Sanjan Das
Researcher at Structural Genomics Consortium
Publications - 3
Citations - 257
Sanjan Das is an academic researcher from Structural Genomics Consortium. The author has contributed to research in topics: Protein kinase domain & SR protein. The author has an hindex of 3, co-authored 3 publications receiving 230 citations.
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Journal ArticleDOI
Structure and Regulation of the Human Nek2 Centrosomal Kinase
P. Rellos,Frank J. Ivins,Joanne E. Baxter,Ashley C. W. Pike,Timothy J. Nott,Donna-Marie Parkinson,Sanjan Das,Steven Howell,Oleg Fedorov,Qi Yu Shen,Andrew M. Fry,Stefan Knapp,Stephen J. Smerdon +12 more
TL;DR: A role for dimerization-dependent allosteric regulation that combines with autophosphorylation and proteinosphatase 1c phosphatase activity to generate the precise spatial and temporal control required for Nek2 function in centrosomal maturation is suggested.
Journal ArticleDOI
Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
Alex N. Bullock,Sanjan Das,Judit É. Debreczeni,P. Rellos,Oleg Fedorov,Frank H. Niesen,Kunde Guo,E. Papagrigoriou,A. Amos,Suhyung Cho,Benjamin E. Turk,Gourisankar Ghosh,Stefan Knapp,Stefan Knapp +13 more
TL;DR: The unconstrained substrate interaction together with the determined active-site mediated substrate specificity allows CLKs to complete the functionally important hyperphosphorylation of splicing factors like ASF/SF2.
Journal ArticleDOI
Structural comparison of human mammalian ste20-like kinases
Christopher J. Record,Apirat Chaikuad,P. Rellos,Sanjan Das,Ashley C. W. Pike,Oleg Fedorov,Brian D. Marsden,Brian D. Marsden,Stefan Knapp,Stefan Knapp,Wen Hwa Lee +10 more
TL;DR: A comparative analysis of the kinase domains for all four members of the human MST family identified new structural features in the MST ATP binding pocket and has also defined the mechanism for autophosphorylation.