J
Joanne E. Baxter
Researcher at University of Leicester
Publications - 11
Citations - 835
Joanne E. Baxter is an academic researcher from University of Leicester. The author has contributed to research in topics: Centrosome & Centriole. The author has an hindex of 10, co-authored 11 publications receiving 781 citations.
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Journal ArticleDOI
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction
Balca R. Mardin,Cornelia Lange,Joanne E. Baxter,Tara Hardy,Sebastian R. Scholz,Andrew M. Fry,Elmar Schiebel +6 more
TL;DR: It is demonstrated that two Hippo pathway components, the mammalian sterile 20-like kinase 2 (Mst2) and the scaffold protein Salvador (hSav1), directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin.
Journal ArticleDOI
A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment
TL;DR: It is shown that Nek2A, which directly binds the APC/C, can be ubiquitylated and destroyed in Fizzy/Cdc20-depleted Xenopus egg extracts when only the N-terminal domain of Fizzy-related/Cdh1 (N-CDC20) is added.
Journal ArticleDOI
Structure and Regulation of the Human Nek2 Centrosomal Kinase
P. Rellos,Frank J. Ivins,Joanne E. Baxter,Ashley C. W. Pike,Timothy J. Nott,Donna-Marie Parkinson,Sanjan Das,Steven Howell,Oleg Fedorov,Qi Yu Shen,Andrew M. Fry,Stefan Knapp,Stephen J. Smerdon +12 more
TL;DR: A role for dimerization-dependent allosteric regulation that combines with autophosphorylation and proteinosphatase 1c phosphatase activity to generate the precise spatial and temporal control required for Nek2 function in centrosomal maturation is suggested.
Journal ArticleDOI
Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases
Joseph Rapley,Joanne E. Baxter,Joelle M. Y. Blot,Samantha L. Wattam,Martina Casenghi,Patrick Meraldi,Erich A. Nigg,Andrew M. Fry +7 more
TL;DR: It is shown that human Nlp and its Xenopus homologue, X-Nlp, are also phosphorylated by the cell cycle-regulated Nek2 kinase, the first example of a protein involved in microtubule organization that is coordinately regulated at the G2/M transition by two centrosomal kinases.
Journal ArticleDOI
Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.
Wenjuan Wu,Joanne E. Baxter,Samantha L. Wattam,Daniel G. Hayward,Margarida Fardilha,Axel Knebel,Eleanor M. Ford,Edgar F. da Cruz e Silva,Andrew M. Fry +8 more
TL;DR: Alternative splicing provides an unusual mechanism for modulating Nek2 localization, enabling it to have both nuclear and cytoplasmic functions.